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STRINGSTRING
AT1G15280 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G15280" - CASC3/Barentsz eIF4AIII binding in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AT1G15280CASC3/Barentsz eIF4AIII binding; Its function is described as molecular_function unknown; Involved in biological_process unknown; Located in cytosol; Expressed in 23 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- CASC3/Barentsz eIF4AIII binding (InterPro-IPR018545); BEST Arabidopsis thaliana protein match is- CASC3/Barentsz eIF4AIII binding (TAIR-AT1G80000.2); Has 4051 Blast hits to 2285 proteins in 311 species- Archae - 2; Bacteria - 232; Metazoa - 1228; Fungi - 302; Plants - 228; Viruses - 67; Other Eukaryotes - 1992 (source- NCBI BLink) (585 aa)    
Predicted Functional Partners:
Y14
RNA-binding (RRM/RBD/RNP motifs) family protein; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA me [...] (202 aa)
     
 
  0.999
MAGO
Protein mago nashi homolog; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby infl [...] (150 aa)
       
 
  0.998
AT5G02530
RNA-binding (RRM/RBD/RNP motifs) family protein; Export adapter involved in nuclear export of spliced and unspliced mRNA; Belongs to the ALYREF family (292 aa)
       
      0.995
AT1G15290
Tetratricopeptide repeat (TPR)-like superfamily protein; Its function is described as binding; Involved in biological_process unknown; Located in cellular_component unknown; Expressed in 24 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Tetratricopeptide-like helical (InterPro-IPR011990), Tetratricopeptide repeat-containing (InterPro-IPR013026), Tetratricopeptide repeat (InterPro-IPR019734); BEST Arabidopsis thaliana protein match is- Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR-AT4G28080.1); Has 30201 Blast hits to 17322 [...] (1608 aa)
           
  0.967
EMB2279
Pentatricopeptide repeat-containing protein At1g30610, chloroplastic; Mutations in this locus result in embryo lethality. Embryo shape at seed maturity is globular (1006 aa)
           
  0.923
AT3G12960
Seed maturation protein; Unknown protein; Has 44 Blast hits to 44 proteins in 14 species- Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 44; Viruses - 0; Other Eukaryotes - 0 (source- NCBI BLink) (86 aa)
           
  0.909
EIF4A-III
Eukaryotic initiation factor 4A-III homolog; ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs througho [...] (408 aa)
           
  0.896
PYM
Partner of Y14 and mago; Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs (By similarity). Can increase in vitro the expression from reporter constructs [...] (204 aa)
           
  0.691
UPF3
Regulator of nonsense transcripts UPF3; Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the pro [...] (484 aa)
     
   
  0.651
AT1G28260
Telomerase activating protein Est1; May play a role in growth and development (880 aa)
           
  0.641
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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