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TPL protein (Arabidopsis thaliana) - STRING interaction network
"TPL" - TOPLESS in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TPLTOPLESS; Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes (PubMed-23034631). Required for ovule development (PubMed-25378179) (1131 aa)    
Predicted Functional Partners:
NINJA
AFP-like protein 2; Acts as a transcriptional repressor. Negative regulator of jasmonate responses. Connects the JAZ proteins and the non-JAZ protein TIFY8 with the TOPLESS corepressors (425 aa)
     
 
  0.981
TRO
TRAUCO; Trithorax-group gene homolog required for early embryogenesis (PubMed-20118203, PubMed-21423667). Required for the expression of FLC and FLC homologs and represses flowering (PubMed-21423667). Required for proper leaf growth and development (PubMed-21423667). Part of COMPASS-like complexes responsible for H3K4 trimethylation, but not for di- or mono-methylation of histone H3 ’Lys-4’ (PubMed-21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed-21423667) (509 aa)
     
 
  0.952
AT3G21060
RbBP5 LIKE; Promotes the expression of FLC and FLC homologs to repress the floral transition (547 aa)
     
 
  0.951
AT3G52100
RING/FYVE/PHD zinc finger-containing protein (696 aa)
     
 
  0.933
AT3G52105
Uncharacterized protein (70 aa)
     
 
  0.928
IAA12
Auxin-responsive protein IAA12; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression (239 aa)
       
 
  0.913
IAA19
Auxin-responsive protein IAA19; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression (197 aa)
       
 
  0.888
ATX2
Trithorax-like protein 2; Histone methyltransferase (1083 aa)
     
 
  0.881
HD1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous floral [...] (501 aa)
     
 
  0.877
AT5G66240
transducin/WD40 domain-containing protein (331 aa)
     
 
  0.863
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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