FDM1 protein (Arabidopsis thaliana) - STRING interaction network
"FDM1" - Factor of DNA methylation 1 in Arabidopsis thaliana
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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Gene Fusion
FDM1Factor of DNA methylation 1; Forms a complex with IDN2 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed-22302148, PubMed-22757778, PubMed-22570638, PubMed-22592791). Required for de novo DNA methylation and 24 nucleotide small interfering RNA (siRNA) accumulation (PubMed-22570638). Binds unmethylated but not methylated DNAs through its coiled-coil domain (PubMed-22757778). May bind double- stranded RNAs (dsRNAs) with 5’-overhangs through its XS domain (PubMed-22302148, PubMed-22757778). However, [...] (634 aa)    
Predicted Functional Partners:
ARGONAUTE 4; Together with RDM3, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci (PubMed-21738482). Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats. Forms a AGO4/NRPE1/siRNA complex in cajal body, facilitating its function in RNA-directed gene silencing of target loci. Required for CpNpG and asymmetric DNA methylation as well as histone H3 ’Lys-9’ methylation (H3K9me) at SUP and SN1 lo [...] (924 aa)
INVOLVED IN DE NOVO 2; Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed-22570638, PubMed-22592791) and downstream of small interfering RNA (siRNA) formation (PubMed-22810086). Required for de novo DNA methylation, siRNA accumulation and siRNA-mediated maintenance methylation (PubMed-19915591). Required for several post-transcriptional gene silencing pathways (PubMed-20059743). Binds double-stranded RNAs (dsRNAs) with 5’-overhangs through its XS domain (PubMed-19915 [...] (647 aa)
DEFECTIVE IN MERISTEM SILENCING 3; Component of the RNA-directed DNA methylation (RdDM) machinery, probably by facilitating an RNAi-mediated epigenetic modification involving secondary siRNAs and spreading of DNA methylation, thus leading to gene silencing. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex. Required for de novo DNA methylation (420 aa)
RNA-dependent RNA polymerase 2; RNA-dependent direct polymerase involved in the production of small interfering RNAs (siRNAs). Required for the biogenesis of endogenous siRNAs of 24 nucleotide which derive from heterochromatin and DNA repeats such as transposons or endogenous gene tandem repeats, such as repeats present in FWA gene. Involved in transcriptional gene silencing (TGS). Component of the RNA- directed DNA methylation (RdDM) silencing pathway that utilizes siRNAs to guide DNA methyltransferases to asymmetric cytosines. Involved in control of flowering time through RdDM of FWA [...] (1133 aa)
Uncharacterized protein (963 aa)
SUPPRESSOR OF GENE SILENCING 3; Required for post-transcriptional gene silencing and natural virus resistance. May bind nucleic acids and is essential for the biogenesis of trans-acting siRNAs but is not required for silencing induced by IR-PTGS. Involved in the juvenile-to-adult transition regulation. In case of begomoviruses infection, it is targeted by the viral protein V2 leading to suppression of post- transcriptional gene silencing (625 aa)
SNF2 and helicase domain-containing protein; Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed-25420628). Associates with SUVR2 and functions redundantly with FRG2. Required for the efficient methylation of a broad range of RdDM target loci (PubMed-25425661) (1047 aa)
Domains rearranged methyltransferase 2; Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation (626 aa)
Nuclear RNA polymerase D1B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements. Also required for full erasure of methylation when the RNA trigger is withdrawn. Seems also involved in the synthesis of short-interfering RNAs (siRNA). Essential component of a self- reinforcing loop coupling de novo DNA methylation to siRNA pr [...] (1976 aa)
RNA-DIRECTED DNA METHYLATION 1; Regulator of RNA-directed DNA methylation (RdDM). Binds to single-stranded methyl DNA. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex (163 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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