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MC8 protein (Arabidopsis thaliana) - STRING interaction network
"MC8" - Metacaspase 8 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
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[Homology]
Score
MC8Metacaspase 8; Cysteine protease that cleaves specifically after arginine residues. Does not cleave caspase-specific substrates. May be involved in the modulation of programmed cell death activated by oxidative stress (381 aa)    
Predicted Functional Partners:
AT5G57060
Uncharacterized protein (137 aa)
           
  0.606
AT3G03370
Uncharacterized protein (244 aa)
     
   
  0.582
AT4G02690
Bax inhibitor-1 family protein (248 aa)
           
  0.555
AT1G03070
Bax inhibitor-1 family protein (247 aa)
           
  0.555
BIL4
BRZ-INSENSITIVE-LONG HYPOCOTYLS 4 (239 aa)
           
  0.540
B120
S-locus lectin protein kinase-like protein (849 aa)
     
   
  0.535
MDHAR
Monodehydroascorbate reductase; Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process (PubMed-16146528). Required for producing sufficient ascorbate to maintain the interaction between Piriformospora indica and Arabidopsis in a mutualistic state (PubMed-19386380) (441 aa)
     
   
  0.506
ATDAD1
DEFENDER AGAINST APOPTOTIC DEATH 1; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Possesses cell death-inhibiting activity (115 aa)
           
  0.491
BZIP60
bZIP transcription factor 60; Transcription factor involved in the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Plays a role in plant immunity and abiotic stress responses (295 aa)
     
   
  0.486
CYP81F2
Cytochrome P450, family 81, subfamily F, polypeptide 2; Involved in indole glucosinolate biosynthesis. Catalyzes hydroxylation reactions of the glucosinolate indole ring. Converts indol-3-yl-methylglucosinolate (I3M) to 4-hydroxy-indol-3-yl- methylglucosinolate (4OH-I3M) and/or 1-hydroxy-indol-3-yl- methylglucosinolate (1OH-I3M) intermediates. These hydroxy intermediates are converted to 4-methoxy-indol-3-yl- methylglucosinolate (4MO-I3M) and 1-methoxy-indol-3-yl- methylglucosinolate (1MO-I3M) by indole glucosinolate methyltransferase 1 and 2 (IGMT1 and IGMT2) (PubMed-21317374). Contri [...] (491 aa)
     
 
  0.481
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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