• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
REV7 protein (Arabidopsis thaliana) - STRING interaction network
"REV7" - Putative translesion synthesis polymerase zeta subunit, homologous to Y-family DNA polymerases, contains BRCT domain. Mutants are sensitive to UV-B radiation. Gene is involved in damage-tolerance mechanisms through translesion synthesis(TLS) in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
REV7Putative translesion synthesis polymerase zeta subunit, homologous to Y-family DNA polymerases, contains BRCT domain. Mutants are sensitive to UV-B radiation. Gene is involved in damage-tolerance mechanisms through translesion synthesis(TLS) (215 aa)    
Predicted Functional Partners:
REV1
DNA-directed DNA polymerases; Deoxycytidyl transferase involved in DNA repair and translesion synthesis (TLS). Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. Mediates also the insertion of dTMP or dGMP when the opposite base is G, and, with a low efficiency, dGMP insertions opposite G, T, and C, dAMP insertions opposite G, A, and T, and dTMP insertion opposite A. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and [...] (1105 aa)
     
  0.999
REV3
Encodes the catalytic subunit of DNA polymerase zeta.Mutants are sensitive to UV-B radiation. Gene is involved in damage-tolerance mechanisms through translesion synthesis(TLS) (1916 aa)
       
  0.999
AT1G49980
DNA/RNA polymerases superfamily protein; Template-directed low-fidelity DNA polymerase specifically involved in DNA repair. Able to extend primer-terminal mispairs, and to insert nucleotides opposite to a single 7,8-dihydro-8-oxoGuanine (8-oxoG) lesion and moderately extend from the resulting primer end, thus leading to both error-free and error-prone bypass of 8- oxoG DNA lesions. Probably involved in consecutive DNA replication cycles in the absence of mitosis. Binds preferentially template-primer DNA substrates or single-stranded DNA. Plays an important role in translesion synthesis [...] (671 aa)
     
  0.991
AT5G66930
Autophagy-related protein 101; Accessory protein involved in autophagy. Acts as scaffold protein of the ATG1-ATG13 complex for faithful delivery of autophagic vesicles to the vacuole. Required for selective mitophagy; Belongs to the ATG101 family (251 aa)
           
  0.943
POLH
Y-family DNA polymerase H; Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV- induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5’-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Ex [...] (672 aa)
       
 
  0.936
RFC1
Replication factor C subunit 1; Plays a role as mediator of transcriptional gene silencing (TGS), DNA replication, DNA repair, hypersensitive response (HR) and telomere length regulation. Is required in meiosis for DNA double-strand break (DSB) repair during meiotic homologous recombination. May participate in the RAD51-mediated recombination intermediate repair process. Is important for lagging strand synthesis. Promotes meiotic recombination via a specific pathway for crossovers (COs) that involves the formation of double Holliday Junction (dHJ) intermediates (956 aa)
         
  0.908
AT1G49180
Serine/threonine-protein kinase ATG1t; Serine/threonine protein kinase involved in autophagy. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery (408 aa)
     
 
  0.905
EMB2810
Replication factor C subunit 5; Encodes a protein with high homology to the Replication Factor C, Subunit 3 (RFC3) of yeast and other eukaryotes. rfc3 mutants are hypersensitive to salicylic acid and exhibit enhanced induction of PR genes and resistance against virulent oomycete Hyaloperonospora arabidopsidis Noco2. The enhanced pathogen resistance in the mutant is NPR1-independent (369 aa)
     
 
    0.903
AT1G53980
Ubiquitin-like superfamily protein; BEST Arabidopsis thaliana protein match is- Ubiquitin-like superfamily protein (TAIR-AT1G53950.1); Has 4877 Blast hits to 1479 proteins in 398 species- Archae - 0; Bacteria - 0; Metazoa - 2141; Fungi - 549; Plants - 1364; Viruses - 11; Other Eukaryotes - 812 (source- NCBI BLink) (91 aa)
       
    0.902
AT1G53950
Ubiquitin-like superfamily protein; Contains the following InterPro domains- Ubiquitin subgroup (InterPro-IPR019956), Ubiquitin (InterPro-IPR000626), Ubiquitin supergroup (InterPro-IPR019955); BEST Arabidopsis thaliana protein match is- Ubiquitin family protein (TAIR-AT4G02890.4); Has 10458 Blast hits to 4586 proteins in 685 species- Archae - 0; Bacteria - 26; Metazoa - 4341; Fungi - 1141; Plants - 2617; Viruses - 325; Other Eukaryotes - 2008 (source- NCBI BLink) (216 aa)
       
    0.902
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (7%) [HD]