STRINGSTRING
SR45 protein (Arabidopsis thaliana) - STRING interaction network
"SR45" - Arginine/serine-rich 45 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SR45Arginine/serine-rich 45; Involved in 5’ and 3’ splicing site selection of introns, and may bridge the 5’ and 3’ components of the spliceosome. Isoform 1 is required during flower petal development and isoform 2 is involved in root growth. Regulates negatively glucose and abscisic acid (ABA) signaling during early seedling development. Involved in the RNA-directed DNA methylation pathway (PubMed-22274613) (425 aa)    
Predicted Functional Partners:
U1-70K
Encodes U1 snRNP 70K; Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA (427 aa)
       
  0.998
SR45a
Serine/arginine rich-like protein 45a; Probable splicing factor involved in constitutive and/or alternative splicing events. May bridge the 5’ and 3’ components of the spliceosome (382 aa)
       
  0.996
RSZ21
RS-containing zinc finger protein 21; Probably involved in intron recognition and spliceosome assembly (187 aa)
     
  0.992
SR34
Pre-mRNA-splicing factor SF2; General splicing factor. Can promote splice site selection in vitro presumably by antagonizing the effects of the A1 heterogeneous nuclear ribonucleoprotein. May have an essential function during early plant development (303 aa)
       
  0.992
SKIP
Chromatin protein family; Splicing factor involved in post-transcriptional regulation of circadian clock and flowering time genes. Associates with the pre-mRNA of PRR7, PRR9, ELF3 and GI, and is necessary for the regulation of their alternative splicing and mRNA maturation. Probably involved in splice site recognition (613 aa)
     
  0.991
RS2Z33
Arginine/serine-rich zinc knuckle-containing protein 33; Splicing factor involved in constitutive and/or alternative splicing. Regulates the splicing of its own pre-mRNA and the alternative splicing of RS30, RS31 and RS34. Associates the cyclin-depedent kinase G1 (CDKG1) with the spliceosome and recruits it to U1 snRNP to facilitate splicing (290 aa)
     
  0.989
U2AF35B
Splicing factor U2af small subunit B; Necessary for the splicing of pre-mRNA (By similarity). Probably active at the 3’ splice sites (283 aa)
     
  0.989
AT1G10580
pre-mRNA-processing factor 17 (573 aa)
       
  0.987
U2B'
U2 small nuclear ribonucleoprotein B; Involved in nuclear pre-mRNA splicing (232 aa)
     
  0.986
SR30
Splicing factor, arginine/serine-rich 1/9; Regulatory splicing factor that modulates alternative splicing and gene expression in specific cell types. Autoregulates its own expression. Probably involved in intron recognition and spliceosome assembly (268 aa)
         
  0.985
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (14%) [HD]