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HAC12 protein (Arabidopsis thaliana) - STRING interaction network
"HAC12" - Histone acetyltransferase of the CBP family 12 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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HAC12Histone acetyltransferase of the CBP family 12; Encodes an enzyme with histone acetyltransferase activity that can use both H3 and H4 histones as substrates. No single prior lysine acetylation is sufficient to block HAC12 acetylation of the H3 or H4 peptides, suggesting that HAC12 can acetylate any of several lysines present in the peptides (1706 aa)    
Predicted Functional Partners:
NRPB1
DNA-directed RNA polymerase II subunit 1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. NRPB1 is part of the core element with the central large clef [...] (1839 aa)
     
  0.960
AT5G55856
Putative small ubiquitin-related modifier 8; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (By similarity); Belongs to the ubiquitin family. SUMO subfamily (97 aa)
       
  0.953
SUMO3
Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (By similarity); Belongs to the ubiquitin family. SUMO subfamily (111 aa)
       
  0.953
SUMO1
Small ubiquitin-related modifier 1; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Required for the massive protein sumoylation in the nucleus induced by heat shock and controlled by SIZ1. Involved in the regulation of the heat stress transcription factor HSFA2 in acquired thermotolerance (100 aa)
       
  0.953
SUMO5
Encodes a small ubiquitin-like modifier (SUMO) protein that becomes covalently attached to various intracellular protein targets through an isopeptide bond. SUMOylation typically has a post-translational effect on the behavior of the target protein (108 aa)
       
  0.953
UVH3
5’-3’ exonuclease family protein; Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3’-incision step in NER. Seems to play a role in senescence program; Belongs to the XPG/RAD2 endonuclease family. XPG subfamily (1479 aa)
     
  0.938
SCE1
SUMO-conjugating enzyme SCE1; Encodes a SUMO liagse that directs the attachment of the small protein SUMO to target proteins via an isopeptide bond. This enzyme is localized to the nucleus and plants with reduced levels of this protein show higher sensitivity to ABA in root growth inhibition assays. It has high similarity to the yeast UBC9 SUMO ligase and is sometimes referred to by that name (160 aa)
       
  0.929
NF-YB11
Putative CCAAT-binding transcription factor subunit; "nuclear factor Y, subunit B11" (NF-YB11); Its function is described as sequence-specific DNA binding transcription factor activity; Involved in regulation of transcription; Located in intracellular; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Transcription factor CBF/NF-Y/archaeal histone (InterPro-IPR003958), Histone-fold (InterPro-IPR009072); BEST Arabidopsis thaliana protein match is- nuclear factor Y, subunit B1 (TAIR-AT2G38880.7); Has 148542 Blast hits to 60498 p [...] (275 aa)
       
  0.928
TFIIS
Encodes RNA polymerase II transcript elongation factor TFIIS. Complements yeast TFIIS mutation. Mutant plants display essentially normal development, but they flower slightly earlier than the wild type and show clearly reduced seed dormancy (378 aa)
       
  0.922
DDB1A
Damaged DNA binding protein 1A; Component of light signal transduction machinery. Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s). Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis- promoting factors such as HY5, HYH and LAF1. Plays a role in DNA repair by forming with DDB2 the UV-damaged DNA-binding protein complex (UV-DDB). Component of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-prote [...] (1088 aa)
     
  0.919
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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