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VPS46.1 protein (Arabidopsis thaliana) - STRING interaction network
"VPS46.1" - Vacuolar protein sorting 46.1 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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VPS46.1Vacuolar protein sorting 46.1; Involved in ESCRT-dependent multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Mediates the MVB sorting of the auxin carriers PIN1, PIN2 and AUX1. Required for embryonic axis establishment and seedling growth. Required for autophagic degradation of plastid proteins. Promotes the efficient sequestration of cargo from plastids into autophagosomes. Mediates the efficient delivery of autophagic plastid bodies to the vacuole, but not into the cytoplasm (203 aa)    
Predicted Functional Partners:
VPS2.2
Vacuolar protein sorting-associated protein 2 homolog 2; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (222 aa)
     
  0.998
EXT-like
Protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Thought to be a cofactor of SKD1/VPS4, which catalyzes the disassembly of membrane-associated ESCRT-III. Target of pathogen-responsive mitogen-activated protein kinases (MPKs) that plays a critical role in plant basal resistance to Pseudomonas syrin [...] (421 aa)
     
  0.998
SKD1
Protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1; Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. May also regulate cell cycle. Required during seed development for the formation of mucilage in seed coat and testa. Involved in the maintenance of Na(+)/K(+) homeostasis under salt stress. Required for cell expansion (435 aa)
     
  0.997
AT1G08270
Vacuolar protein sorting-associated protein; Contains the following InterPro domains- MIT (InterPro-IPR007330); BEST Arabidopsis thaliana protein match is- AAA-type ATPase family protein (TAIR-AT2G27600.1); Has 35333 Blast hits to 34131 proteins in 2444 species- Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source- NCBI BLink) (132 aa)
     
  0.990
VPS24.1
Vacuolar protein sorting-associated protein 24 homolog 1; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (229 aa)
     
 
  0.989
SNF7.1
Vacuolar protein sorting-associated protein 32 homolog 2; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (219 aa)
     
 
  0.987
VPS24.2
Putative vacuolar protein sorting-associated protein 24 homolog 2; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity); Belongs to the SNF7 family (200 aa)
     
 
  0.987
SNF7.2
Vacuolar protein sorting-associated protein 32 homolog 1; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity); Belongs to the SNF7 family (213 aa)
     
 
  0.985
VPS2.1
Vacuolar protein sorting-associated protein 2 homolog 1; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity); Belongs to the SNF7 family (225 aa)
     
0.976
VPS60.1
Vacuolar protein sorting-associated protein 60.1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs; Belongs to the SNF7 family (235 aa)
     
 
  0.974
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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