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STRINGSTRING
CSTF77 protein (Arabidopsis thaliana) - STRING interaction network
"CSTF77" - Tetratricopeptide repeat in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CSTF77Tetratricopeptide repeat (TPR)-like superfamily protein; One of the multiple factors required for polyadenylation and 3’-end cleavage of pre-mRNAs (By similarity). Required for the targeted 3’ processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene (734 aa)    
Predicted Functional Partners:
CSTF64
Cleavage stimulating factor 64; One of the multiple factors required for polyadenylation and 3’-end cleavage of pre-mRNAs (By similarity). This subunit is directly involved in the binding to pre-mRNAs, especially on the 3’ non-coding region. Required for the targeted 3’ processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene (461 aa)
      
  0.999
FIP1[V]
Homolog of yeast FIP1 [V]; Essential gene. Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity) (1196 aa)
      
  0.999
CPSF100
Encodes a protein similar to the 100kD subunit of cleavage and polyadenylation specificity factor (CPSF), the factor responsible for the recognition of the AAUAAA motif during mRNA polyadenylation. The protein interacts with a portion of a nuclear poly(A) polymerase. It is likely to be a part of the mRNA 3’end formation apparatus (739 aa)
      
  0.999
AT5G60940
Transducin/WD40 repeat-like superfamily protein; One of the multiple factors required for polyadenylation and 3’-end cleavage of pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (429 aa)
      
  0.999
CPSF30
30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium-dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3’ ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a prel [...] (631 aa)
      
 
  0.999
AT5G43620
Polyadenylation and cleavage factor homolog 5; Pre-mRNA cleavage complex II; Its function is described as zinc ion binding; Involved in biological_process unknown; Located in intracellular; Contains the following InterPro domains- Zinc finger, C2H2-type (InterPro-IPR007087); BEST Arabidopsis thaliana protein match is- Pre-mRNA cleavage complex II (TAIR-AT1G66500.1); Has 1807 Blast hits to 1807 proteins in 277 species- Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source- NCBI BLink) (410 aa)
      
  0.999
AT1G66500
Polyadenylation and cleavage factor homolog 1; Pre-mRNA cleavage complex II; Its function is described as zinc ion binding; Involved in biological_process unknown; Located in intracellular; Expressed in male gametophyte, pollen tube; Expressed during L mature pollen stage, M germinated pollen stage; Contains the following InterPro domains- Zinc finger, C2H2-type (InterPro-IPR007087); BEST Arabidopsis thaliana protein match is- Pre-mRNA cleavage complex II (TAIR-AT5G43620.1); Has 382 Blast hits to 380 proteins in 159 species- Archae - 0; Bacteria - 0; Metazoa - 108; Fungi - 132; Plants [...] (416 aa)
      
  0.999
AT1G27595
Symplekin; Contains the following InterPro domains- Symplekin tight junction protein C-terminal (InterPro-IPR022075); BEST Arabidopsis thaliana protein match is- HEAT repeat-containing protein (TAIR-AT5G01400.1); Has 593 Blast hits to 297 proteins in 111 species- Archae - 0; Bacteria - 3; Metazoa - 139; Fungi - 49; Plants - 57; Viruses - 0; Other Eukaryotes - 345 (source- NCBI BLink) (961 aa)
      
  0.999
AT1G27590
At1g27590; Contains the following InterPro domains- Protein of unknown function DUF3453 (InterPro-IPR021850); BEST Arabidopsis thaliana protein match is- phosphatidylinositol 3- and 4-kinase family protein (TAIR-AT1G27570.1); Has 109 Blast hits to 109 proteins in 38 species- Archae - 0; Bacteria - 0; Metazoa - 65; Fungi - 4; Plants - 38; Viruses - 0; Other Eukaryotes - 2 (source- NCBI BLink) (264 aa)
      
  0.999
CPSF160
Cleavage and polyadenylation specificity factor subunit 1; CPSF plays a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction; Belongs to the CPSF1 family (1442 aa)
      
  0.999
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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