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AT1G18090 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G18090" - 5'-3' exonuclease family protein in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
AT1G180905’-3’ exonuclease family protein; Its function is described as DNA binding, catalytic activity, nuclease activity; Involved in DNA repair; Located in cellular_component unknown; Expressed in 22 plant structures; Expressed during 14 growth stages; Contains the following InterPro domains- XPG conserved site (InterPro-IPR019974), XPG N-terminal (InterPro-IPR006085), DNA repair protein (XPGC)/yeast Rad (InterPro-IPR006084), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), Helix-hairpin-helix motif, class 2 (InterPro-IPR008918), XPG/RAD2 endonuclease (InterPro-IPR0060 [...] (577 aa)    
Predicted Functional Partners:
MSH2
DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers- MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effe [...] (937 aa)
   
  0.994
MLH1
DNA mismatch repair protein MLH1; Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is [...] (737 aa)
     
  0.993
PMS1
DNA mismatch repair protein, putative; Required for DNA mismatch repair (MMR), correcting base- base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the ge [...] (923 aa)
     
  0.992
MRE11
Double-strand break repair protein MRE11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand- specific 3’-5’ exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family (720 aa)
   
  0.991
emb2411
DNA replication helicase, putative; Embryo defective 2411 (emb2411); Its function is described as ATP-dependent DNA helicase activity, DNA binding, ATP binding; Involved in DNA replication, embryo development ending in seed dormancy; Located in chloroplast; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- DNA helicase, UvrD/REP type (InterPro-IPR000212), DNA replication factor Dna2 (InterPro-IPR014808); BEST Arabidopsis thaliana protein match is- DNA-binding protein, putative (TAIR-AT2G03270.1) (1315 aa)
   
 
  0.990
RAD50
DNA repair-recombination protein (RAD50); Implicated in double-strand breaks (DSBs) repair by non- homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division; Belongs to the SMC family. RAD50 subfamily (1316 aa)
   
  0.988
ATM
Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR) or DNA replication stalling. Plays a central role in the perception and response to both stress-induced damage in somatic cells and developmentally programmed DNA damage during meiosis. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Involved in transcriptional regulation of RAD51, PARP1, [...] (3845 aa)
     
  0.987
PCNA1
Proliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand; Belongs to the PCNA family (263 aa)
     
  0.981
PCNA2
Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (By similarity). May be involved in UV resistance; Belongs to the PCNA family (264 aa)
     
  0.980
RECQI1
ATP-dependent DNA helicase Q-like 1; 3’-5’ DNA helicase that may play a role in the repair of DNA; Belongs to the helicase family. RecQ subfamily (606 aa)
   
  0.978
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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