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EBS5 protein (Arabidopsis thaliana) - STRING interaction network
"EBS5" - ERAD-associated E3 ubiquitin-protein ligase component HRD3A in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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EBS5ERAD-associated E3 ubiquitin-protein ligase component HRD3A; Component of the endoplasmic reticulum (ER) quality control system called ER-associated degradation (ERAD) and involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Functions as an ERAD substrate- recruiting factor that recognizes misfolded proteins for the HRD1 E3 ubiquitin ligase complex. Targets the misfolded LRR receptor kinase BRI1 (678 aa)    
Predicted Functional Partners:
OS9
Protein OS-9 homolog; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Targets the misfolded LRR receptor kinase BRI1 and the misfolded receptor-like kinase EFR; Belongs to the OS-9 family (282 aa)
     
  0.999
Hrd1A
ERAD-associated E3 ubiquitin-protein ligase HRD1A; Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3B (492 aa)
     
  0.990
Hrd1B
ERAD-associated E3 ubiquitin-protein ligase HRD1B; Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3A (460 aa)
     
  0.989
DER1
DERLIN-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins (266 aa)
     
  0.987
CDC48
Encodes a cell division cycle protein, a member of AAA-type ATPases gene family. Expressed throughout the plant in regions of cell division. Within the cell, sub-cellular localization varies depending on the stage of the cell cycle.Mutants in which the expression of CDC48A is altered show defects in cytokinesis, cell expansion and cell differentiation (809 aa)
   
  0.980
DER2.1
DERLIN-2.1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins (244 aa)
     
  0.980
DER2.2
DERLIN-2.2; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins (244 aa)
     
  0.978
AtCDC48B
Cell division control protein 48 homolog D; Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity) (815 aa)
   
  0.965
AtCDC48C
Cell division control protein 48 homolog E; Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity) (810 aa)
   
  0.963
AT4G32670
RING/FYVE/PHD zinc finger superfamily protein; Its function is described as zinc ion binding; Expressed during seedling growth; Contains the following InterPro domains- Zinc finger, C3HC4 RING-type (InterPro-IPR018957), Zinc finger, RING-CH-type (InterPro-IPR011016); BEST Arabidopsis thaliana protein match is- RING/U-box superfamily protein (TAIR-AT4G34100.2); Has 2175 Blast hits to 1953 proteins in 226 species- Archae - 0; Bacteria - 2; Metazoa - 1020; Fungi - 225; Plants - 544; Viruses - 49; Other Eukaryotes - 335 (source- NCBI BLink) (860 aa)
         
  0.951
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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