STRINGSTRING
ICS2 protein (Arabidopsis thaliana) - STRING interaction network
"ICS2" - Isochorismate synthase 2 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ICS2Isochorismate synthase 2; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity (562 aa)    
Predicted Functional Partners:
PHYLLO
PHYLLO; Multifunctional enzyme required for phylloquinone (vitamin K1) biosynthesis (1715 aa)
   
 
0.985
CM2
Chorismate mutase 2 (265 aa)
   
 
  0.920
CM1
Chorismate mutase 1; May play a role in chloroplast biogenesis (340 aa)
   
 
  0.918
CM3
Chorismate mutase 3; May play a role in chloroplast biogenesis (316 aa)
   
 
  0.918
EMB1144
Chorismate synthase; Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway (436 aa)
       
  0.910
AT5G57890
Anthranilate synthase component II; Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate (By similarity) (273 aa)
   
 
  0.892
AT1G25155.1
Anthranilate synthase component II (222 aa)
   
 
  0.892
AT1G24807
Anthranilate synthase component II (235 aa)
   
 
  0.891
ASB1
Anthranilate synthase beta subunit 1; Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate. Plays an important regulatory role in auxin production via the tryptophan-dependent biosynthetic pathway (289 aa)
   
 
  0.891
NIC2
Nicotinamidase 2; Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Prevents the accumulation of intracellular nicotinamide, a known inhibitor of poly(ADP-ribose) polymerases (PARP enzymes). May play a role in the regulation of seed germination potential (198 aa)
   
 
  0.857
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]