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BES1 protein (Arabidopsis thaliana) - STRING interaction network
"BES1" - BRI1-EMS-SUPPRESSOR 1 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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BES1BRI1-EMS-SUPPRESSOR 1; Positive brassinosteroid-signaling protein. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5’-CANNTG-3’(E box) through its N-terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C-terminal domain is probably involved in transcriptional activation (357 aa)    
Predicted Functional Partners:
BIN2
BRASSINOSTEROID-INSENSITIVE 2; Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5 (380 aa)
       
 
  0.992
BRI1
BRASSINOSTEROID INSENSITIVE 1; Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Phosphoryla [...] (1196 aa)
           
  0.959
BSU1
BRI1 SUPPRESSOR 1; Phosphatase that acts as a positive regulator of brassinosteroid (BR) signaling (PubMed-14977918, PubMed-21855796). Dephosphorylates BES1, a transcription factor that regulates the expression of BR-response genes, thereby playing an important role in the regulation of response to BRs (PubMed-14977918). Inactivates the negative regulator of BR signaling ASK7/BIN2 by dephosphorylation at ’Tyr-200’ (PubMed-21855796) (793 aa)
           
  0.955
BZR1
BRASSINAZOLE-RESISTANT 1; Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5’-CGTG(T/C)G-3’ in gene promoter. Regulates positively the brassinosteroid-signaling pathway. Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis. Promotes growth. Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e.g. HLL, ANT, and AP2) (336 aa)
     
0.919
IWS1
Transcription elongation factor (TFIIS) family protein (502 aa)
       
 
  0.917
BKI1
BRI1 kinase inhibitor 1; Negative regulator of brassinosteroid signaling. When associated to the membrane, limits the interaction of BRI1 with BAK1 by binding to the kinase-inactive form of BRI1 (337 aa)
     
   
  0.915
ELF6
EARLY FLOWERING 6; Acts probably as a histone ’Lys-4’ (H3K4me) demethylase. Involved in transcriptional gene regulation. Acts as a repressor of the photoperiodic flowering pathway and of FT. Binds around the transcription start site of the FT locus (1340 aa)
       
 
  0.913
DWF4
DWARF 4; Catalyzes the C22-alpha-hydroxylation step in brassinosteroids biosynthesis. Converts campestanol to 6- deoxocathasterone and 6-oxocampestanol to cathasterone (513 aa)
           
  0.911
BIM1
Transcription factor BIM1; Positive brassinosteroid-signaling protein. Transcription factor that bind specifically to the DNA sequence 5’-CANNTG-3’(E box). Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BZR2/BES1. Does not itself activate transcription but enhances BZR2/BES1-mediated target gene activation (532 aa)
       
 
  0.903
MYB30
Myb domain protein 30; Transcription factor that binds specifically to the DNA sequence 5’-AACAAAC-3’ (PubMed-19170933). Acts as a positive regulator of hypersensitive cell death (PubMed-10571865, PubMed-12119395). Acts as a positive regulator of salicylic acid synthesis (PubMed-16730712). Regulates very-long-chain fatty acid biosynthesis (PubMed-18326828). Acts cooperatively with BZR2 to promote expression of a subset of brassinosteroids target genes (PubMed-19170933). Transcriptional activity and hypersensitive response control negatively regulated by PLA2-ALPHA and by the Xanthomona [...] (323 aa)
       
 
  0.900
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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