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DHAR1 protein (Arabidopsis thaliana) - STRING interaction network
"DHAR1" - Dehydroascorbate reductase in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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DHAR1Dehydroascorbate reductase; Displays a dual function. As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Key component of the ascorbate recycling system. Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses, subsequently to biotic or abiotic inducers. As a peripheral membrane protein, could also function as voltage-gated ion channel (213 aa)    
Predicted Functional Partners:
MDHAR
Monodehydroascorbate reductase; Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process (PubMed-16146528). Required for producing sufficient ascorbate to maintain the interaction between Piriformospora indica and Arabidopsis in a mutualistic state (PubMed-19386380) (441 aa)
           
  0.958
GR
Glutathione reductase; Maintains high levels of reduced glutathione in the chloroplast (565 aa)
           
  0.923
APX1
Ascorbate peroxidase 1; Plays a key role in hydrogen peroxide removal. Constitutes a central component of the reactive oxygen gene network (250 aa)
           
  0.866
APX3
Ascorbate peroxidase 3; Plays a key role in hydrogen peroxide removal (287 aa)
           
  0.808
VTC2
Vitamin c defective 2; Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Acts as a phosphorylase rather than as a transferase. Uses preferentially GDP-L-galactose and GDP-D-glucose as substrates. Lower activity with GDP-L-fucose, very low activity with GDP-D-mannose, and no activity with UDP-D-glucose, UDP-D-galactose or ADP-D-glucose. Highly specific for inorganic phosphate as the guanylyl acceptor (442 aa)
           
  0.803
GSTF9
Glutathione S-transferase; In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC), and glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide. May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides (215 aa)
     
   
  0.762
CYT1
CYTOKINESIS DEFECTIVE 1; Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Plays an essential role in plant growth and development and cell-wall architecture. Provides GDP-mannose, used for cell wall carbohydrate biosynthesis, protein N-glycosylation, as well as for the biosynthesis of the antioxidant ascorbate (361 aa)
           
  0.740
GLDH
L-galactono-1,4-lactone dehydrogenase; Involved in the biosynthesis of ascorbic acid. Required for the accumulation of respiratory complex I. Uses L-galactono- 1,4-lactone and L-gulono-1,4-lactone as substrates, but not D- galactono-1,4-lactone, D-gulono-1,4-lactone, L-mannono-1,4-lactone or D-galactonic acid. Also active with phenazine methosulfate and 1,4-benzoquinone as electron acceptors (610 aa)
           
  0.739
GSTU19
Glutathione S-transferase TAU 19; Catalyzes the glutathionylation of 12-oxophytodienoate (OPDA). In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC), and glutathione peroxidase activity toward cumene hydroperoxide (219 aa)
   
     
  0.705
GLX1
Glyoxalase I homolog; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (322 aa)
     
   
  0.685
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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