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AT1G20720 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G20720" - RAD3-like DNA-binding helicase protein in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AT1G20720RAD3-like DNA-binding helicase protein; Its function is described as in 6 functions; Involved in nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; Located in mitochondrion; Expressed in 8 plant structures; Expressed during 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; Contains the following InterPro domains- DEAD2 (InterPro-IPR010614), Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type (InterPro-IPR014013), Helicase-like, DEXD box c2 type (InterPro-IPR006554), DNA helicase (DN [...] (1175 aa)    
Predicted Functional Partners:
BARD1
BRCA1-associated RING domain protein 1; Binds specifically to H3K4me3 regions of target genes (e.g. WUS and WOX5) promoters to repress their transcription via chromatin remodeling. Required for the shoot apical meristem (SAM) organization and maintenance, by confining WUS expression to the organizing center, and for the quiescent center (QC) development in the root apical meristem (RAM), by repressing WOX5 expression in the root proximal meristem. Plays a role in DNA repair and in cell-cycle control. Required for the repair of DNA double-strand breaks (DSBs), both natural and induced b [...] (714 aa)
     
  0.958
emb2411
DNA replication helicase, putative; Embryo defective 2411 (emb2411); Its function is described as ATP-dependent DNA helicase activity, DNA binding, ATP binding; Involved in DNA replication, embryo development ending in seed dormancy; Located in chloroplast; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- DNA helicase, UvrD/REP type (InterPro-IPR000212), DNA replication factor Dna2 (InterPro-IPR014808); BEST Arabidopsis thaliana protein match is- DNA-binding protein, putative (TAIR-AT2G03270.1) (1315 aa)
   
 
  0.956
BRCA1
Encodes AtBRCA1, an ortholog of the human breast cancer susceptibility gene 1. Contains one N-terminal RING finger, two C-terminal BRCT and the p300/CBP interacting domain. Strongly induced by gamma rays, consistent with a putative role in DNA repair and in cell cycle control (941 aa)
     
  0.953
AT1G18090
5’-3’ exonuclease family protein; Its function is described as DNA binding, catalytic activity, nuclease activity; Involved in DNA repair; Located in cellular_component unknown; Expressed in 22 plant structures; Expressed during 14 growth stages; Contains the following InterPro domains- XPG conserved site (InterPro-IPR019974), XPG N-terminal (InterPro-IPR006085), DNA repair protein (XPGC)/yeast Rad (InterPro-IPR006084), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), Helix-hairpin-helix motif, class 2 (InterPro-IPR008918), XPG/RAD2 endonuclease (InterPro-IPR0060 [...] (577 aa)
     
  0.950
AT1G29630
5’-3’ exonuclease family protein; Putative 5’->3’ double-stranded DNA exonuclease which may also contain a cryptic 3’->5’ double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity); Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily (735 aa)
     
  0.949
BRCA2(IV)
Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I (1187 aa)
     
 
  0.949
BRCA2B
Protein BREAST CANCER SUSCEPTIBILITY 2 homolog B; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I (1155 aa)
     
 
  0.947
ATM
Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR) or DNA replication stalling. Plays a central role in the perception and response to both stress-induced damage in somatic cells and developmentally programmed DNA damage during meiosis. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Involved in transcriptional regulation of RAD51, PARP1, [...] (3845 aa)
     
 
  0.937
RAD51C
RAS associated with diabetes protein 51C; Encodes a protein similar to RAD51C involved in double stranded break repair via homologous recombination. Sensitive to DSB induced by Mitomycin C and gamma irradiation, interacts with Atxrcc3 in yeast two-hybrid assay. Required for female meiosis but not critical for mitosis under normal conditions; Belongs to the RecA family. RAD51 subfamily (387 aa)
   
  0.937
XRCC2
Homolog of X-ray repair cross complementing 2 (XRCC2); Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions (372 aa)
     
 
  0.933
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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