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OGG1 protein (Arabidopsis thaliana) - STRING interaction network
"OGG1" - 8-oxoguanine-DNA glycosylase 1 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
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Gene Fusion
OGG18-oxoguanine-DNA glycosylase 1; Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3’ to the lesion; Belongs to the type-1 OGG1 family (365 aa)    
Predicted Functional Partners:
DNA-(apurinic or apyrimidinic site) lyase; Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting. According to a report, displays also an in vitro 3’-phosphatase activity. According to another report, has no in vitro 3’-phosphatase activity. Catalyzes the conversion of the 3’-blocking groups 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) generated by ROS1 to 3’-OH. Has a strong non-specific affinity to DNA. Redundant with APE2 and at least one functional allele is required for seed viability (364 aa)
DNA-(apurinic or apyrimidinic site) lyase, chloroplastic; Repairs oxidative DNA damages, seems also to act as a redox factor. Is multifunctional and may be involved both in DNA repair and in the regulation of transcription. Exhibits apurinic/apyrimidinic (AP) endonuclease activity. Catalyzes the conversion of 3’-phosphor-alpha,beta-unsaturated aldehyde (3’-PUA) to 3’-OH. May be involved in base excision repair in chloroplasts. According to a report, has a significant in vitro 3’-phosphatase activity. According to another report, has no in vitro 3’-phosphatase activity. Has a strong non [...] (536 aa)
HhH-GPD base excision DNA repair family protein; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities (By similarity) (630 aa)
Uracil-DNA glycosylase, mitochondrial; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. More active on U-G, U-T and U-C mispairs than on U-A pairs. Highly specific for uracil and no activity with 5-substituted uracil or cytosine derivatives. Required for initiation of base excision repair (BER) of uracil (330 aa)
BRCT domain-containing DNA repair protein; Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (By similarity). Involved in DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation (353 aa)
DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers- MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effe [...] (937 aa)
Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH3 heterodimers bound ’insertion-deletion’ DNA with three nucleotides (+AAG) or one nucleotide (+T) looped out much better than they bound DNA with a base/base mispair (T/G) (1081 aa)
5’-3’ exonuclease family protein; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated fla [...] (453 aa)
Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] (410 aa)
Endonuclease/exonuclease/phosphatase family protein; Exhibits apurinic/apyrimidinic (AP) endonuclease activity in vitro. By contrast, another report show that APE2 has no biochemical activity. Unable to catalyze the conversion of 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) to 3’-OH. Has no in vitro 3’-phosphatase activity. Redundant with APE1L and at least one functional allele is required for seed viability. Has a strong non-specific affinity to DNA (610 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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