OGG1 protein (Arabidopsis thaliana) - STRING interaction network
"OGG1" - 8-oxoguanine-DNA glycosylase 1 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
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Gene Fusion
OGG18-oxoguanine-DNA glycosylase 1; Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3’ to the lesion (365 aa)    
Predicted Functional Partners:
DNAse I-like superfamily protein; Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting (PubMed-25569774). According to a report, displays also an in vitro 3’-phosphatase activity (PubMed-25569774). According to another report, has no in vitro 3’-phosphatase activity (PubMed-25228464). Catalyzes the conversion of the 3’-blocking groups 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) generated by ROS1 to 3’-OH (PubMed-25228464, PubMed-25569774). Has a strong non-specific affinity to DNA (PubMed-25228464). Redundant with APE2 and at least [...] (364 aa)
Apurinic endonuclease-redox protein; Repairs oxidative DNA damages, seems also to act as a redox factor (PubMed-7512729). Is multifunctional and may be involved both in DNA repair and in the regulation of transcription (PubMed-7512729). Exhibits apurinic/apyrimidinic (AP) endonuclease activity (PubMed-25569774, PubMed-21781197, PubMed-25228464). Catalyzes the conversion of 3’-phosphor-alpha,beta-unsaturated aldehyde (3’-PUA) to 3’-OH (PubMed-25228464). May be involved in base excision repair in chloroplasts (PubMed-19372224). According to a report, has a significant in vitro 3’-phospha [...] (536 aa)
Endonuclease 2; Exhibits apurinic/apyrimidinic (AP) endonuclease activity in vitro (PubMed-25569774). By contrast, another report show that APE2 has no biochemical activity (PubMed-25228464). Unable to catalyze the conversion of 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) to 3’-OH (PubMed-25228464, PubMed-25569774). Has no in vitro 3’-phosphatase activity (PubMed-25228464, PubMed-25569774). Redundant with APE1L and at least one functional allele is required for seed viability (PubMed-19172180). Has a strong non-specific affinity to DNA (PubMed-25228464) (610 aa)
Endonuclease III; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines (379 aa)
Flap endonuclease-1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (453 aa)
Proliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (263 aa)
Y-family DNA polymerase H; Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV- induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5’-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Ex [...] (672 aa)
Protein ROS1; Bifunctional DNA glycosylase/lyase, which excises 5- methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed-25240767). Generates 3’-phosphor- alpha,beta-unsaturated aldehyde (3’-PUA) as a primary 5-meC excision intermediate (PubMed-25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. [...] (1393 aa)
Uracil dna glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. More active on U-G, U-T and U-C mispairs than on U-A pairs. Highly specific for uracil and no activity with 5-substituted uracil or cytosine derivatives. Required for initiation of base excision repair (BER) of uracil (330 aa)
Calcium-dependent lipid-binding (CaLB domain) family protein (509 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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