• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
OGG1 protein (Arabidopsis thaliana) - STRING interaction network
"OGG1" - 8-oxoguanine-DNA glycosylase 1 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OGG18-oxoguanine-DNA glycosylase 1; Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3’ to the lesion; Belongs to the type-1 OGG1 family (365 aa)    
Predicted Functional Partners:
AT3G48425
DNA-(apurinic or apyrimidinic site) lyase; Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting. According to a report, displays also an in vitro 3’-phosphatase activity. According to another report, has no in vitro 3’-phosphatase activity. Catalyzes the conversion of the 3’-blocking groups 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) generated by ROS1 to 3’-OH. Has a strong non-specific affinity to DNA. Redundant with APE2 and at least one functional allele is required for seed viability (364 aa)
   
  0.991
ARP
DNA-(apurinic or apyrimidinic site) lyase, chloroplastic; Repairs oxidative DNA damages, seems also to act as a redox factor. Is multifunctional and may be involved both in DNA repair and in the regulation of transcription. Exhibits apurinic/apyrimidinic (AP) endonuclease activity. Catalyzes the conversion of 3’-phosphor-alpha,beta-unsaturated aldehyde (3’-PUA) to 3’-OH. May be involved in base excision repair in chloroplasts. According to a report, has a significant in vitro 3’-phosphatase activity. According to another report, has no in vitro 3’-phosphatase activity. Has a strong non [...] (536 aa)
   
  0.984
AT4G12740
HhH-GPD base excision DNA repair family protein; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities (By similarity) (630 aa)
   
   
  0.963
UNG
Uracil-DNA glycosylase, mitochondrial; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. More active on U-G, U-T and U-C mispairs than on U-A pairs. Highly specific for uracil and no activity with 5-substituted uracil or cytosine derivatives. Required for initiation of base excision repair (BER) of uracil (330 aa)
     
   
  0.931
ATXRCC1
BRCT domain-containing DNA repair protein; Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (By similarity). Involved in DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation (353 aa)
     
 
  0.918
MSH2
DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers- MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effe [...] (937 aa)
     
 
  0.917
MSH3
Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH3 heterodimers bound ’insertion-deletion’ DNA with three nucleotides (+AAG) or one nucleotide (+T) looped out much better than they bound DNA with a base/base mispair (T/G) (1081 aa)
     
 
  0.917
AT5G26680
5’-3’ exonuclease family protein; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated fla [...] (453 aa)
   
 
  0.916
ERCC1
Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] (410 aa)
     
   
  0.914
AT4G36050
Endonuclease/exonuclease/phosphatase family protein; Exhibits apurinic/apyrimidinic (AP) endonuclease activity in vitro. By contrast, another report show that APE2 has no biochemical activity. Unable to catalyze the conversion of 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) to 3’-OH. Has no in vitro 3’-phosphatase activity. Redundant with APE1L and at least one functional allele is required for seed viability. Has a strong non-specific affinity to DNA (610 aa)
   
 
  0.903
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (7%) [HD]