• Version:
  • 11.0 (preview - - version 10.5 still available here)
AT1G21730 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G21730" - P-loop containing nucleoside triphosphate hydrolases superfamily protein in Arabidopsis thaliana
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
AT1G21730P-loop containing nucleoside triphosphate hydrolases superfamily protein; Its function is described as microtubule motor activity, ATP binding; Involved in microtubule-based movement; Located in plasma membrane; Expressed in 9 plant structures; Expressed during F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; Contains the following InterPro domains- Kinesin, motor region, conserved site (InterPro-IPR019821), Kinesin, motor domain (InterPro-IPR001752); BEST Arabidopsis thaliana protein match is- P-loop containing nucleoside [...] (890 aa)    
Predicted Functional Partners:
Mitochondrial outer membrane protein porin 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective (By similarity); Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family (274 aa)
Uncharacterized protein T14E10_200; Contains the following InterPro domains- Kinetochore protein Ndc80 (InterPro-IPR005550); Has 24780 Blast hits to 15608 proteins in 1321 species- Archae - 545; Bacteria - 2969; Metazoa - 12597; Fungi - 2181; Plants - 1581; Viruses - 39; Other Eukaryotes - 4868 (source- NCBI BLink) (568 aa)
Uncharacterized protein At1g77720; Encodes a predicted protein kinase based on sequence similarity (777 aa)
Mitotic spindle checkpoint protein MAD2; Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (209 aa)
Myosin family protein with Dil domain; Myosin heavy chain that is required for the cell cycle- regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in trafficking of Golgi stacks, mitochondria and peroxisomes (1529 aa)
Microtubule-associated protein 65-9 (MAP65-9); Contains the following InterPro domains- Microtubule-associated protein, MAP65/ASE1-type (InterPro-IPR007145); BEST Arabidopsis thaliana protein match is- Microtubule associated protein (MAP65/ASE1) family protein (TAIR-AT5G51600.1); Has 14792 Blast hits to 10558 proteins in 786 species- Archae - 349; Bacteria - 1217; Metazoa - 7703; Fungi - 921; Plants - 837; Viruses - 44; Other Eukaryotes - 3721 (source- NCBI BLink) (549 aa)
Microtubule associated protein (MAP65/ASE1) family protein; Microtubule-associated protein that plays a critical role in organizing the mitotic microtubule array during both early and late mitosis in all plant organs. Essential for the cytokinesis, especially in roots, by maintaining the integrity of the overlapped microtubules in the phragmoplast. Required during root morphogenesis. Needed for giant cell development during root knot nematode infection, where cytokinesis is initiated but not completed; Belongs to the MAP65/ASE1 family (707 aa)
Ubiquinol oxidase 2, mitochondrial; Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity); Belongs to the alternative oxidase family (353 aa)
Mad3/BUB1 homology region 1; Contains the following InterPro domains- Mitotic checkpoint serine/threonine protein kinase, Bub1 (InterPro-IPR015661), Mad3/BUB1 homology region 1 (InterPro-IPR013212); BEST Arabidopsis thaliana protein match is- BUB1-related (BUB1- budding uninhibited by benzymidazol 1) (TAIR-AT2G33560.2); Has 1807 Blast hits to 1807 proteins in 277 species- Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source- NCBI BLink) (471 aa)
BUB1-related (BUB1- budding uninhibited by benzymidazol 1); Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions may be to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C (By similarity) (396 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (8%) [HD]