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MBD8 protein (Arabidopsis thaliana) - STRING interaction network
"MBD8" - Methyl-CpG-binding domain-containing protein 8 in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MBD8Methyl-CpG-binding domain-containing protein 8; Probable transcriptional regulator (By similarity). May regulates developmental traits such as flowering time (524 aa)    
Predicted Functional Partners:
MBD11
Methyl-CpG-binding domain-containing protein 11; Transcriptional regulator that binds DNA independently of its methylation status. Required during plant organogenesis and development (254 aa)
           
  0.837
MBD1
Protein containing methyl-CpG-binding domain (204 aa)
           
  0.832
MBD10
Methyl-CpG-binding domain-containing protein 10; Probable transcriptional regulator (By similarity). Required for nucleolar dominance that consist in the silencing of rRNA genes inherited from one progenitor in genetic hybrids (384 aa)
           
  0.795
MBD02
Protein containing methyl-CpG-binding domain.Has sequence similarity to human MBD proteins (272 aa)
           
  0.765
MBD4
Methyl-CpG-binding domain-containing protein 4; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing (186 aa)
           
  0.760
MBD6
Methyl-CpG-binding domain-containing protein 6; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing. May associate with histone deacetylase proteins (HDAC). Required for nucleolar dominance that consist in the silencing of rRNA genes inherited from one progenitor in genetic hybrids. Recruited to rRNA genes in a DRM2-dependent manner (225 aa)
           
  0.739
MBD7
Methyl-CpG-binding domain-containing protein 7; Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression. Requires high mCG density for binding. Recognizes preferentially mCGs located in transposable elements. Required for active DNA demethylation. Prefers to target genomic loci [...] (306 aa)
           
  0.732
MBD9
Encodes a protein with a methyl-CpG-binding domain. Has sequence similarity to human MBD proteins. Involved in the modification of the FLC chromatin acetylation state to affect FLC expression. Mutants show an early flowering, and enhanced shoot branching phenotypes (2176 aa)
           
  0.698
MEE57
DNA (cytosine-5-)-methyltransferase family protein; Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells (By similarity). Required during the endosperm development in seeds; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family (1404 aa)
           
  0.430
LOH1
Uncharacterized CRM domain-containing protein At3g25440, chloroplastic; RNA-binding CRS1 / YhbY (CRM) domain protein; Its function is described as RNA binding; Involved in biological_process unknown; Located in chloroplast; Expressed in shoot apex, embryo, leaf whorl, flower, seed; Expressed during petal differentiation and expansion stage, E expanded cotyledon stage; Contains the following InterPro domains- RNA-binding, CRM domain (InterPro-IPR001890); BEST Arabidopsis thaliana protein match is- RNA-binding CRS1 / YhbY (CRM) domain protein (TAIR-AT4G13070.1); Has 778 Blast hits to 674 [...] (444 aa)
     
        0.412
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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