STRINGSTRING
MBD8 protein (Arabidopsis thaliana) - STRING interaction network
"MBD8" - methyl-CPG-binding domain 8 in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
MBD8methyl-CPG-binding domain 8; Probable transcriptional regulator (By similarity). May regulates developmental traits such as flowering time (524 aa)    
Predicted Functional Partners:
MBD3
methyl-CPG-binding domain 3; Probable transcriptional regulator (163 aa)
           
  0.911
MBD5
methyl-CPG-binding domain protein 5; Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C). Plays probably a role in gene silencing (182 aa)
           
  0.868
MBD1
methyl-CPG-binding domain 1; Probable transcriptional regulator (204 aa)
           
  0.866
MBD4
methyl-CPG-binding domain 4; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing (186 aa)
           
  0.866
MBD7
methyl-CPG-binding domain 7; Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression (PubMed-25684209). Requires high mCG density for binding (PubMed-25684209, PubMed-25593350). Recognizes preferentially mCGs located in transposable elements (PubMed-25684209, PubMed-25593350). [...] (306 aa)
           
  0.864
MBD6
methyl-CPG-binding domain 6; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing. May associate with histone deacetylase proteins (HDAC). Required for nucleolar dominance that consist in the silencing of rRNA genes inherited from one progenitor in genetic hybrids. Recruited to rRNA genes in a DRM2-dependent manner (225 aa)
           
  0.861
MBD02
methyl-CPG-binding domain protein 02; Probable transcriptional regulator (272 aa)
           
  0.861
AT4G22740
Glycine-rich protein (356 aa)
           
  0.809
AT4G15730
CW-type Zinc Finger (1059 aa)
           
  0.809
AT3G62900
CW-type Zinc Finger (1465 aa)
           
  0.809
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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