• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
AT1G22860 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G22860" - Vacuolar sorting protein 39 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AT1G22860Vacuolar sorting protein 39; Its function is described as small GTPase regulator activity; Involved in biological_process unknown; Located in cellular_component unknown; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Citron-like (InterPro-IPR001180), Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1 (InterPro-IPR019452), Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 (InterPro-IPR019453); Has 401 Blast hits to 372 proteins in 133 species- Arc [...] (961 aa)    
Predicted Functional Partners:
AT1G12470
Zinc ion binding; Its function is described as zinc ion binding; Expressed in 24 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Pep3/Vps18/deep orange (InterPro-IPR007810), Zinc finger, RING-type (InterPro-IPR001841); Has 495 Blast hits to 471 proteins in 206 species- Archae - 0; Bacteria - 2; Metazoa - 170; Fungi - 162; Plants - 42; Viruses - 0; Other Eukaryotes - 119 (source- NCBI BLink) (988 aa)
     
  0.999
VPS11
Homologous to yeast VPS11. Forms a complex with VCL1 and AtVPS33. Involved in vacuolar biogenesis; Belongs to the VPS11 family (932 aa)
     
  0.999
VCL1
Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen (858 aa)
     
  0.996
ATVPS33
Homologous to yeast VPS33. Forms a complex with VCL1 and AtVPS11. Involved in vacuolar biogenesis (608 aa)
     
  0.995
VPS41
Vacuolar protein sorting-associated protein 41 homolog; Might be involved in protein sorting to the vacuole (980 aa)
     
  0.993
VAMP727
Encodes a member of Synaptobrevin -like protein family. VAMP727 is a R-SNARE and interacts with SYP22/VTI11/SYP51. It is required for trafficking of storage proteins to the protein storage vacuoles (PSV) and also for PSV organization and biogenesis. Loss of function mutations have no phenotype but double mutants with SYP22 are embryo lethal (240 aa)
     
  0.975
AT1G16020
Vacuolar fusion protein CCZ1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. In complex with MON1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation (515 aa)
     
   
  0.955
SETH5
Transducin family protein / WD-40 repeat family protein; Its function is described as binding, zinc ion binding; Involved in biological_process unknown; Located in cellular_component unknown; Expressed in 13 plant structures; Expressed during 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; Contains the following InterPro domains- WD40 repeat 2 (InterPro-IPR019782), Zinc finger, RING-type (InterPro-IPR001841), WD40 repeat, conserved site (InterPro-IPR019775), WD40 repeat (InterPro-IPR001680), WD40 repeat-like-c [...] (1913 aa)
     
 
  0.945
AT2G28390
Vacuolar fusion protein MON1 homolog; Plays an important role in membrane trafficking through the secretory apparatus. In complex with CCZ1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation (607 aa)
     
 
  0.922
RAB7B
Ras-related protein RABG3f; Essential for trafficking from prevacuolar compartments to vacuoles. Involved in the trafficking of newly synthesized protein to vacuoles. Essential for plant growth. Participates in the recruitment of the core retromer components to the endosomal membrane by interacting with VPS35A (206 aa)
       
 
  0.887
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (9%) [HD]