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TH1 protein (Arabidopsis thaliana) - STRING interaction network
"TH1" - THIAMINE REQUIRING 1 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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TH1THIAMINE REQUIRING 1; Essential for thiamine biosynthesis. Bifunctional enzyme that catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP and condenses 4-methyl-5-(beta- hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino- 5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (522 aa)    
Predicted Functional Partners:
THIC
thiaminC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (644 aa)
 
  0.998
AT3G24030
Hydroxyethylthiazole kinase; Thiazole kinase involved in thiamine salvage pathway (276 aa)
 
 
  0.997
PDXH
Pyridoxin (pyrodoxamine) 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP). Involved in the PLP salvage pathway. Has a higher preference for PNP over PMP. May also catalyze the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (530 aa)
   
 
  0.908
AT3G16990
Haem oxygenase-like, multi-helical; Involved in thiamine salvage by hydrolyzing the thiamine breakdown product 4-amino-5-aminomethyl-2-methylpyrimidine (amino- HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) (PubMed-25014715). Has a high formylamino-HMP amidohydrolase activity (PubMed-25014715). No activity with other thiamine degradation products such as thiamine mono- or diphosphate, oxothiamine, oxythiamine, thiamine disulfide, desthiothiamine or thiochrome as substrates (PubMed-25014715). Does not display thiaminase II activity, as it is unable to hydrolyze thiamine (PubMe [...] (221 aa)
   
  0.901
AT5G66005
Expressed protein (192 aa)
         
    0.900
CNX5
Sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from th [...] (464 aa)
   
   
  0.839
THI1
Thiazole biosynthetic enzyme; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (349 aa)
   
   
  0.838
FMN/FHY
Riboflavin kinase; Bifunctional enzyme that catalyzes the hydrolysis of flavin-mononucleotide (FMN) to riboflavin (vitamin B2) and the phosphorylation of riboflavin to form (FMN) coenzyme (379 aa)
       
  0.838
AT4G30000
Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis (561 aa)
         
  0.795
AT1G69190
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase/dihydropteroate synthase; Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis (PubMed-17289662). Plays a role in seed stress response and survival (PubMed-17289662, PubMed-21996493) (484 aa)
         
  0.795
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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