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FRO3 protein (Arabidopsis thaliana) - STRING interaction network
"FRO3" - Ferric reduction oxidase 3, mitochondrial in Arabidopsis thaliana
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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FRO3Ferric reduction oxidase 3, mitochondrial; Ferric chelate reductase involved in iron reduction in roots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates (717 aa)    
Predicted Functional Partners:
PYE
Basic helix-loop-helix (bHLH) DNA-binding superfamily protein; Encodes POPEYE (PYE), a bHLH transcription factor regulating response to iron deficiency in Arabidopsis roots (240 aa)
     
   
  0.911
NAS4
Probable nicotianamine synthase 4; Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron (324 aa)
           
  0.901
BHLH101
Basic helix-loop-helix (bHLH) DNA-binding superfamily protein; BHLH101; Its function is described as DNA binding, sequence-specific DNA binding transcription factor activity; Involved in regulation of transcription; Located in nucleus; Expressed in root, leaf; Expressed during LP.04 four leaves visible; Contains the following InterPro domains- Helix-loop-helix DNA-binding domain (InterPro-IPR001092), Helix-loop-helix DNA-binding (InterPro-IPR011598); BEST Arabidopsis thaliana protein match is- basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR-AT3G56970.1); Has 1807 Bl [...] (240 aa)
     
   
  0.862
FER4
Ferritin-4, chloroplastic; Encodes FERRITIN 4, AtFER4. Ferritins are a class of 24-mer multi-meric proteins found in all kingdoms of life. Function as the main iron store in mammals. Evidence suggests that Arabidopsis ferritins are essential to protect cells against oxidative damage, but they do not constitute the major iron pool. Localize to mitochondria. Knock out mutants are not sensitive to abiotic stress (259 aa)
           
  0.862
NRAMP4
Natural resistance associated macrophage protein 4; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP3 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP3, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts (512 aa)
     
   
  0.855
OPT3
Oligopeptide transporter 3; May be involved in the translocation of tetra- and pentapeptides across the cellular membrane in an energy-dependent manner. Acts also as a metal transporter that could be a component of the copper transport machinery. Essential for early embryo development (737 aa)
     
   
  0.854
ZIF1
Encodes ZIF1 (ZINC-INDUCED FACILITATOR1), a member of the Major Facilitator Superfamily (MFS) of membrane proteins which are found in all organisms and transport a wide range of small, organic molecules. Involved in a mechanism of Zn sequestration, possibly by transport of a Zn ligand or Zn-ligand complex into vacuoles (486 aa)
     
   
  0.852
bHLH39
Encodes a member of the basic helix-loop-helix transcription factor protein (258 aa)
     
   
  0.850
IRT1
Iron-regulated transporter 1; High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions (347 aa)
     
   
  0.847
ORG1
Probable plastid-lipid-associated protein 14, chloroplastic; Directly regulated by DOF3.6/OBP3; unknown function (670 aa)
     
   
  0.834
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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