• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
GGAT1 protein (Arabidopsis thaliana) - STRING interaction network
"GGAT1" - Glutamate--glyoxylate aminotransferase 1 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GGAT1Glutamate--glyoxylate aminotransferase 1; Catalyzes the glutamate-glyoxylate (GGT or GGAT), alanine-glyoxylate (AGT), alanine-2-oxoglutarate (AKT) and glutamate-pyruvate (GPT) aminotransferase reactions in peroxisomes. Required for abscisic acid (ABA)- and stress-mediated responses in an H(2)O(2)-dependent manner. Function as a photorespiratory aminotransferase that modulates amino acid content during photorespiration (GGAT activity); promotes serine, glycine and citrulline metabolism in response to light (481 aa)    
Predicted Functional Partners:
GLU1
Ferredoxin-dependent glutamate synthase 1, chloroplastic/mitochondrial; Encodes a gene whose sequence is similar to ferredoxin dependent glutamate synthase (Fd-GOGAT). Expression in leaves is induced by light and sucrose. Proposed to be involved in photorespiration and nitrogen assimilation (1648 aa)
   
  0.996
HPR
Glycerate dehydrogenase HPR, peroxisomal; Catalyzes the NADH-dependent reduction of hydroxypyruvate into glycerate in the photorespiratory core cycle. Mediates fatty acid beta-oxidation in germinating seeds when malate dehydrogenase is absent (387 aa)
   
 
  0.995
AGT
Serine--glyoxylate aminotransferase; Photorespiratory enzyme that catalyzes transamination reactions with multiple substrates, including asparagine. Function exclusively as a catabolic enzyme in Asn metabolism; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family (401 aa)
   
  0.994
SHM1
Encodes a protein with mitochondrial serine hydroxymethyltransferase activity, which functions in the photorespiratory pathway, catalyzes the conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Involved in controlling cell damage caused by abiotic stress, such as high light and salt and the hypersensitive defense response of plants; Belongs to the SHMT family (517 aa)
     
 
  0.985
GLU2
Ferredoxin-dependent glutamate synthase 2, chloroplastic; May play a role in primary nitrogen assimilation in roots. Could supply a constitutive level of glutamate to maintain a basal level of protein synthesis (1629 aa)
   
  0.971
GLDP1
Glycine dehydrogenase (decarboxylating) 1, mitochondrial; The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity) (1037 aa)
   
 
  0.971
AGT2
Alanine-glyoxylate aminotransferase 2 homolog (AGT2) mRNA,; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family (476 aa)
         
  0.947
GS2
Glutamine synthetase, chloroplastic/mitochondrial; The light-modulated chloroplast/mitochondrial enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration; Belongs to the glutamine synthetase family (430 aa)
   
  0.943
GOX2
Aldolase-type TIM barrel family protein; Its function is described as glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; Involved in oxidation reduction, metabolic process; Located in peroxisome; Expressed in guard cell, leaf; Contains the following InterPro domains- Aldolase-type TIM barrel (InterPro-IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro-IPR008259), FMN-dependent dehydrogenase (InterPro-IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro-IPR012133); BEST Arabidopsis thaliana protein match [...] (373 aa)
   
 
  0.941
PPDK
Encodes a dual-targeted protein believed to act as a pyruvate, orthophosphate dikinase. These enzymes are normally associated with C4 photosynthesis which does not occur in Arabidopsis. However, PPDK may play a role in remobilizing nitrogen during leaf senescence in Arabidopsis. The product of the long transcript (.1 gene model) was shown to be targeted to the chloroplast, whereas the shorter transcript (no targeting sequence) accumulates in the cytosol. The two proteins were also found to be expressed in slightly different tissues (963 aa)
     
 
  0.935
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (9%) [HD]