• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
KCS5 protein (Arabidopsis thaliana) - STRING interaction network
"KCS5" - Encodes KCS5, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids) in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCS5Encodes KCS5, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids) (492 aa)    
Predicted Functional Partners:
KCR1
Very-long-chain 3-oxoacyl-CoA reductase 1; Encodes one of the two Arabidopsis homologues to YBR159w encoding a S. cerevisiae beta-ketoacyl reductase (KCR), which catalyzes the first reduction during VLCFA (very long chain fatty acids, >18 carbon) elongation- KCR1 (At1g67730), KCR2 (At1g24470). Complementation of the yeast ybr159Delta mutant demonstrated that the two KCR proteins are divergent and that only AtKCR1 can restore heterologous elongase activity similar to the native yeast KCR gene; Belongs to the short-chain dehydrogenases/reductases (SDR) family (318 aa)
     
 
  0.880
CER2
HXXXD-type acyl-transferase family protein; Involved in biosynthesis of the epicuticular wax. Plays a role in very-long-chain fatty acid (VLCFA) biosynthesis and is required for C28 fatty acid elongation in stem. Despite its classification as a BAHD acyltransferase based on sequence homology, CER2 does not seem to share the catalytic mechanism of the members of the BAHD family (421 aa)
     
   
  0.828
AT5G02890
HXXXD-type acyl-transferase family protein; Its function is described as transferase activity, transferring acyl groups other than amino-acyl groups, transferase activity; Involved in biological_process unknown; Located in cellular_component unknown; Expressed in 21 plant structures; Expressed during 12 growth stages; Contains the following InterPro domains- Transferase (InterPro-IPR003480); BEST Arabidopsis thaliana protein match is- HXXXD-type acyl-transferase family protein (TAIR-AT4G29250.1); Has 524 Blast hits to 524 proteins in 51 species- Archae - 0; Bacteria - 2; Metazoa - 0; F [...] (353 aa)
     
   
  0.747
KCR2
Very-long-chain 3-oxoacyl-CoA reductase-like protein At1g24470; Encodes one of the two Arabidopsis homologues to YBR159w encoding a S. cerevisiae beta-ketoacyl reductase (KCR), which catalyzes the first reduction during VLCFA (very long chain fatty acids, >18 carbon) elongation- KCR1 (At1g67730), KCR2 (At1g24470). Complementation of the yeast ybr159Delta mutant demonstrated that the two KCR proteins are divergent and that only AtKCR1 can restore heterologous elongase activity similar to the native yeast KCR gene (312 aa)
           
  0.742
AT4G13840
HXXXD-type acyl-transferase family protein; Involved in biosynthesis of the epicuticular wax. Plays a role in very-long-chain fatty acid (VLCFA) biosynthesis and is required for C30 fatty acid elongation in leaf. Despite its classification as a BAHD acyltransferase based on sequence homology, CER26 does not seem to share the catalytic mechanism of the members of the BAHD family (428 aa)
     
   
  0.708
AT5G20840
Phosphoinositide phosphatase family protein; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (831 aa)
           
  0.700
PAS2
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PASTICCINO 2; Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes [...] (230 aa)
     
   
  0.686
CER10
3-oxo-5-alpha-steroid 4-dehydrogenase family protein; Catalyzes the last of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as prec [...] (310 aa)
     
   
  0.666
AT3G23840
HXXXD-type acyl-transferase family protein; Involved in biosynthesis of the epicuticular wax. Plays a role in very-long-chain fatty acid (VLCFA) biosynthesis and is required for VLCFA elongation in leaf. Despite its classification as a BAHD acyltransferase based on sequence homology, CER26L does not seem to share the catalytic mechanism of the members of the BAHD family (By similarity) (420 aa)
     
   
  0.636
AT3G14240
Subtilisin-like protease SBT1.5; Subtilase family protein; Its function is described as identical protein binding, serine-type endopeptidase activity; Involved in proteolysis, negative regulation of catalytic activity; Located in endomembrane system; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Protease-associated PA (InterPro-IPR003137), Proteinase inhibitor, propeptide (InterPro-IPR009020), Peptidase S8/S53, subtilisin/kexin/sedolisin (InterPro-IPR000209), Peptidase S8, subtilisin-related (InterPro-IPR015500), Peptidase [...] (775 aa)
     
   
  0.633
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (9%) [HD]