• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
AT1G26200 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G26200" - TRAM, LAG1 and CLN8 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AT1G26200TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein; Its function is described as molecular_function unknown; Involved in biological_process unknown; Located in integral to membrane; Contains the following InterPro domains- Longevity assurance, LAG1/LAC1 (InterPro-IPR016439), TRAM/LAG1/CLN8 homology domain (InterPro-IPR006634); BEST Arabidopsis thaliana protein match is- LAG1 longevity assurance homolog 3 (TAIR-AT1G13580.3); Has 1245 Blast hits to 1245 proteins in 221 species- Archae - 0; Bacteria - 0; Metazoa - 593; Fungi - 293; Plants - 188; Viruses - 3; Other Eukaryote [...] (312 aa)    
Predicted Functional Partners:
AT3G58490
Phosphatidic acid phosphatase (PAP2) family protein; Functions as sphingoid long-chain base phosphate (LCBP) phosphatase. May play a role in the regulation of LCBP levels and be involved in stomatal responses through LCBP-mediated ABA signaling; Belongs to the type 2 lipid phosphate phosphatase family (416 aa)
     
 
  0.698
LCB1
Long chain base biosynthesis protein 1; Encodes the LCB1 subunit of serine palmitoyltransferase. Together with the LCB2 subunit, forms a functional serine palmitoyltransferase complex, which catalyzes the first reaction of sphingolipid biosynthesis. Knockout of LCB1 was embryo lethal. Partial suppression of LCB1 expression led to smaller plants due to reduced cell expansion (482 aa)
     
   
  0.633
ATCES1
Alkaline phytoceramidase (aPHC); Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity (By similarity). Affects plant morphogenesis. Required for the formation of wax layer that ensure cuticle permeability. Implicated in abscisic acid (ABA)-mediated stomatal closure. Involved in both biotic and abiotic stresses. Promotes salt resistance and defenses responses toward pathogenic bacteria (e.g. P.syringae) and against the fungal toxin fumonisin B1 (FB1); Belongs to the alkaline ceramidase family (255 aa)
       
 
  0.610
AT1G80380
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Catalyzes the concluding reaction of the photorespiratory C2 cycle, an indispensable ancillary metabolic pathway to the photosynthetic C3 cycle that enables land plants to grow in an oxygen-containing atmosphere (456 aa)
           
  0.584
DES-1-LIKE
Sphingolipid delta(4)-desaturase DES1-like; Encodes a sphingolipid delta4-desaturase, involved in sphingolipid biosynthesis. Specifically expressed in floral tissues. Knockout mutants were devoid of sphinga-4,8-dienine in floral tissues (332 aa)
           
  0.581
TROL
Rhodanese-like domain-containing protein 4, chloroplastic; Hydroxyproline-rich glycoprotein family protein, contains a rhodanese homology domain. Required for anchoring the FNR flavoenzyme to the thylakoid membranes and sustaining high efficiency photosynthetic linear electron flow (466 aa)
           
  0.581
PK1
Serine/threonine-protein kinase AtPK1/AtPK6; Encodes a protein-serine kinase that phosphorylates ribosomal protein in vitro. Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Involved in translational up-regulation of ribosomal proteins. Phosphorylated by PDK1. Interacts with RAPTOR1, which in turn interacts with TOR. SPK6 activity is affected by osmotic stress, and plants overexpressing S6k1 are hypersensitive to osmotic stress. The gene is expressed in all tissues examined, with highest expression level det [...] (465 aa)
     
 
  0.571
S6K2
Serine/threonine-protein kinase AtPK2/AtPK19; Encodes a ribosomal-protein S6 kinase. Gene expression is induced by cold and salt (NaCl). Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Phosphorylates specifically mammalian and plant S6 at 25 degrees C but not at 37 degrees C. Involved in translational up-regulation of ribosomal proteins; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily (471 aa)
     
 
  0.571
DPMS1
Nucleotide-diphospho-sugar transferases superfamily protein; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex. Plays a role in plant development and physiology, sensitivity to ammonium stress and endoplasmic reticulum stress response (246 aa)
       
 
  0.570
AT5G42000
Uncharacterized protein At5g42000; ORMDL family protein; Its function is described as molecular_function unknown; Involved in protein folding; Located in integral to membrane, endoplasmic reticulum; Expressed in 24 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- ORMDL (InterPro-IPR007203); BEST Arabidopsis thaliana protein match is- ORMDL family protein (TAIR-AT1G01230.1); Has 1807 Blast hits to 1807 proteins in 277 species- Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source- NCBI [...] (154 aa)
       
 
  0.541
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]