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NRPA2 protein (Arabidopsis thaliana) - STRING interaction network
"NRPA2" - Nuclear RNA polymerase A2 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NRPA2Nuclear RNA polymerase A2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and NRPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (1178 aa)    
Predicted Functional Partners:
NRPA1
Nuclear RNA polymerase A1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from NRPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by actin [...] (1670 aa)
   
  0.999
NRPC1
Nuclear RNA polymerase C1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from NRPC1 and crosses the cleft near the catalytic site and is thought to promote translocation [...] (1391 aa)
   
  0.999
ATRPAC42
DNA-directed RNA polymerase subunit (375 aa)
   
  0.999
NRPD1B
Nuclear RNA polymerase D1B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements. Also required for full erasure of methylation when the RNA trigger is withdrawn. Seems also involved in the synthesis of short-interfering RNAs (siRNA). Essential component of a self- reinforcing loop coupling de novo DNA methylation to siRNA pr [...] (1976 aa)
   
  0.999
NRPB1
RNA polymerase II large subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. NRPB1 is part of the core element with the central large cleft, the cl [...] (1839 aa)
   
  0.999
RPOC1
RNA polymerase beta’ subunit-1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (680 aa)
   
  0.999
RPOC2
RNA polymerase beta’ subunit-2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (1376 aa)
   
  0.999
NRPD1A
Nuclear RNA polymerase D1A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Largest and catalytic component of RNA polymerase IV which mediates 24-nt short-interfering RNAs (siRNA) accumulation. Implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4, and subsequent DNA methylation-dependent silencing of targeted sequences. Essential component of a self-reinforcing loop coupling de novo DNA methylation to siRNA production. Required for intercellular but [...] (1453 aa)
   
  0.999
AT3G13940
DNA binding;DNA-directed RNA polymerases (442 aa)
     
 
  0.998
AT3G05060
Putative nucleolar protein 5-2; Required for 60S ribosomal subunit biogenesis (533 aa)
     
 
  0.997
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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