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MNS3 protein (Arabidopsis thaliana) - STRING interaction network
"MNS3" - Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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MNS3Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3; Class I alpha-mannosidase essential for early N-glycan processing. Removes preferentially alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2). Involved in root development and cell wall biosynthesis; Belongs to the glycosyl hydrolase 47 family (624 aa)    
Predicted Functional Partners:
CGL1
Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, putative; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Required for normal root growth and morphology (444 aa)
     
 
  0.987
RSW3
Glycosyl hydrolases family 31 protein; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (By similarity). Essential for stable accumulation of the receptor EFR that determines the specific perception of bacterial elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Required for sustained activation of EFR-mediated signaling, but not receptor FLS2-mediated signaling elicited by the bacterial flagellin flg22 (921 aa)
     
 
  0.970
OS9
Protein OS-9 homolog; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Targets the misfolded LRR receptor kinase BRI1 and the misfolded receptor-like kinase EFR; Belongs to the OS-9 family (282 aa)
           
  0.935
EBS1
UDP-glucose-glycoprotein glucosyltransferase; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Required for elongation factor Tu receptor (EFR), but not flagellin-sensing 2 (FLS2) signaling (1614 aa)
     
   
  0.882
MNS1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1; Class I alpha-mannosidase essential for early N-glycan processing. Progressively trim alpha-1,2-linked mannose residues. Produces Man(5)GlcNAc(2) from Man(8)GlcNAc(2), but only Man(6)GlcNAc(2) from Man(9)GlcNAc(2). Have difficulty acting on the terminal mannose of the b-branch. Involved in root development and cell wall biosynthesis; Belongs to the glycosyl hydrolase 47 family (560 aa)
   
 
0.840
MNS2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS2; Class I alpha-mannosidase essential for early N-glycan processing. Progressively trim alpha-1,2-linked mannose residues. Produces Man(5)GlcNAc(2) from Man(8)GlcNAc(2), but only Man(6)GlcNAc(2) from Man(9)GlcNAc(2). Have difficulty acting on the terminal mannose of the b-branch. Involved in root development and cell wall biosynthesis (572 aa)
   
   
0.839
AT1G73570
ERAD-associated E3 ubiquitin-protein ligase component HRD3B; May be involved in the endoplasmic reticulum (ER) quality control system called ER-associated degradation (ERAD) (604 aa)
           
  0.806
EBS3
Dol-P-Man-Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Curculin-like (mannose-binding) lectin family protein, very low similarity to Ser Thr protein kinase GI-2598067 from (Zea mays); contains Pfam lectin (probable mannose binding) domain PF01453 but not the protein kinase domain of the Z. mays protein; Belongs to the glycosyltransferase 22 family (570 aa)
           
  0.790
ALG3
Dol-P-Man-Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Required for N-linked oligosaccharide assembly. Adds the sixth mannose residue in an alpha-1,3 linkage onto the dolichol- PP-oligosaccharide precursor dolichol-PP-Man(5)GlcNAc(2) (438 aa)
           
  0.782
STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex [...] (735 aa)
     
   
  0.775
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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