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AT1G30680 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G30680" - Toprim domain-containing protein in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AT1G30680Toprim domain-containing protein; Has both DNA primase and DNA helicase activities and may be involved in organelle DNA replication. Capable of producing RNA primers of 9 to 18 bases from a single-stranded DNA template (709 aa)    
Predicted Functional Partners:
RECQ4A
ATP-dependent DNA helicase Q-like 4A; 3’-5’ DNA helicase that may play a role in the repair of DNA. Required for maintenance of genome stability by modulation of the DNA damage response and repression of crossovers. Confers resistance to genotoxic stress (1188 aa)
     
   
  0.911
TOP3A
Topoisomerase 3alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] (926 aa)
           
  0.842
RMI1
Uncharacterized protein (677 aa)
     
   
  0.807
RECQ4B
RECQ helicase L4B; 3’-5’ DNA helicase that may play a role in the repair of DNA (By similarity). Required to promote but not to suppress crossovers (1150 aa)
           
  0.778
RecQl3
ATP-dependent DNA helicase Q-like 3; 3’-5’ DNA helicase that may play a role in the repair of DNA. Exhibits an ATP or dATP-dependent DNA-helicase activity. Can not use GTP/dGTP, CTP/dCTP or UTP/dUTP as nucleotide cofactors. Catalyzes DNA strand annealing. On nicked Holliday junctions, unwinds the lagging strand. Can not act on intact Holliday junctions (713 aa)
           
  0.710
AT4G10890
Uncharacterized protein (527 aa)
           
  0.677
RECQL2
RECQ helicase L2; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (705 aa)
           
  0.677
MUS81
MMS AND UV SENSITIVE 81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5’-end at the branch nick. Typical substrates include 3’- flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombinati [...] (659 aa)
           
  0.676
AT4G31210
DNA topoisomerase, type IA, core (1284 aa)
     
   
  0.651
WRNEXO
Werner Syndrome-like exonuclease; Exonuclease that digests recessed strands of DNA duplexes in the 3’ to 5’ direction but hardly single-stranded DNA or blunt-ended duplexes. Also able to digest 3’-protruding strands and 3’-recessed strand termini of duplexes containing mismatched bases (288 aa)
           
  0.633
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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