• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
SUF4 protein (Arabidopsis thaliana) - STRING interaction network
"SUF4" - Zinc finger (C2H2 type) family protein in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SUF4Zinc finger (C2H2 type) family protein; Encodes SUF4 (SUPPRESSOR of FRI 4), a putative zinc-finger-containing transcription factor that is required for delayed flowering in winter-annual Arabidopsis. suf4 mutations strongly suppress the late-flowering phenotype of FRI (FRIGIDA) mutants. suf4 mutants also show reduced H3K4 trimethylation at FLC (FLOWERING LOCUS C), a floral inhibitor. SUF4 may act to specifically recruit a putative histone H3 methyltransferase EFS (EARLY FLOWERING IN SHORT DAYS) and the PAF1-like complex to the FLC locus (367 aa)    
Predicted Functional Partners:
FRI
Inactive protein FRIGIDA; Encodes a major determinant of natural variation in Arabidopsis flowering time. Dominant alleles of FRI confer a vernalization requirement causing plants to overwinter vegetatively. Many early flowering accessions carry loss-of-function fri alleles .Twenty distinct haplotypes that contain non-functional FRI alleles have been identified and the distribution analyzed in over 190 accessions. The common lab strains- Col and Ler each carry loss of function mutations in FRI (314 aa)
       
 
  0.983
BUB3.1
Transducin/WD40 repeat-like superfamily protein; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20 (By similarity). Essential for gametophyte [...] (340 aa)
     
 
  0.971
FRL1
FRIGIDA-like protein 1; Required for FRI-mediated up-regulation of FLC transcripts, but not redundant with FRI and only partially redundant with FRL2. Required for the stabilization of the FRI-C complex; Belongs to the Frigida family (470 aa)
       
 
  0.957
FLC
MADS-box protein encoded by FLOWERING LOCUS C - transcription factor that functions as a repressor of floral transition and contributes to temperature compensation of the circadian clock. Expression is downregulated during cold treatment. Vernalization, FRI and the autonomous pathway all influence the state of FLC chromatin. Both maternal and paternal alleles are reset by vernalization, but their earliest activation differs in timing and location. Histone H3 trimethylation at lysine 4 and histone acetylation are associated with active FLC expression, whereas histone deacetylation and h [...] (196 aa)
       
 
  0.913
FES1
Zinc finger C-x8-C-x5-C-x3-H type family protein; Transcriptional activator involved in the FRIGIDA- mediated vernalization pathway, but not in the autonomous flowering pathway. Acts cooperatively with FRI (FRIGIDA) or FRL1 (FRIGIDA-LIKE 1) to promote FLC (FLOWERING LOCUS C) expression. Required for the stabilization of the FRI-C complex (587 aa)
           
  0.892
AT1G69400
Transducin/WD40 repeat-like superfamily protein; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20 (By similarity); Belongs to the WD repeat [...] (314 aa)
     
 
  0.890
BUB3.2
Transducin/WD40 repeat-like superfamily protein; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20 (By similarity) (339 aa)
     
 
  0.890
LD
Homeodomain-like superfamily protein; Encodes a nuclear localized protein with similarity to transcriptional regulators. Recessive mutants are late flowering. Expression of LFY is reduced in LD mutants (953 aa)
       
 
  0.883
AT2G32600
Hydroxyproline-rich glycoprotein family protein; Its function is described as zinc ion binding, nucleic acid binding; Involved in biological_process unknown; Located in nucleus, intracellular, spliceosomal complex; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Zinc finger, C2H2-like (InterPro-IPR015880), Zinc finger, U1-type (InterPro-IPR003604), Zinc finger, C2H2-type matrin (InterPro-IPR000690); Has 18078 Blast hits to 8181 proteins in 576 species- Archae - 26; Bacteria - 1885; Metazoa - 7255; Fungi - 1800; Plants - 3678 [...] (277 aa)
     
 
  0.872
EFS
Histone methyltransferases(H3-K4 specific);histone methyltransferases(H3-K36 specific); Histone methyltransferase involved in di and tri- methylation of ’Lys-36’ of histone H3 (H3K36me2 and H3K36me3). Binds to H3 already mono- or di-methylated on ’Lys-4’(H3K4me1 or H3K4me2), but not to H3K4me3. H3K4me and H3K36me represent specific tags for epigenetic transcriptional activation. Regulates positively FLC transcription to prevent early flowering transition. Required for flowering transition in response to vernalization and for the maintenance of FLC expression in late embryos, but dispen [...] (1805 aa)
       
 
  0.869
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (8%) [HD]