SUF4 protein (Arabidopsis thaliana) - STRING interaction network
"SUF4" - Suppressor of FRIGIDA4 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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Gene Fusion
SUF4Suppressor of FRIGIDA4; Sequence-specific DNA binding factor that recognizes the 5’-CCAAATTTTAAGTTT-3’ sequence. Recruites the FRI-C complex to the FLC promoter. Required for FRI-mediated FLC activation, but has no effect on the expression of MAF1, MAF2, MAF3, MAF5, UFC and CO. Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development (367 aa)    
Predicted Functional Partners:
FRIGIDA (314 aa)
FRIGIDA like 1; Required for FRI-mediated up-regulation of FLC transcripts, but not redundant with FRI and only partially redundant with FRL2. Required for the stabilization of the FRI-C complex (470 aa)
Mad3/BUB1 homology region 1 (471 aa)
ATP binding;protein kinases;protein serine/threonine kinases; Serine/threonine-protein kinase that performs 2 crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C). Necessary for ensuring proper chromosome segregation. Can regulate chromosome segregation in a kinetochore- independent manner. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-as [...] (525 aa)
Cell cycle arrest protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20 (By similarity). Essential for gametophyte development (340 aa)
Luminidependens; Seems to play a role in the regulation of flowering time in the autonomous flowering pathway by repressing FLOWERING LOCUS C expression (953 aa)
FRIGIDA-ESSENTIAL 1; Transcriptional activator involved in the FRIGIDA- mediated vernalization pathway, but not in the autonomous flowering pathway. Acts cooperatively with FRI (FRIGIDA) or FRL1 (FRIGIDA-LIKE 1) to promote FLC (FLOWERING LOCUS C) expression. Required for the stabilization of the FRI-C complex (587 aa)
FLOWERING LOCUS C; Putative transcription factor that seems to play a central role in the regulation of flowering time in the late- flowering phenotype by interacting with ’FRIGIDA’, the autonomous and the vernalization flowering pathways. Inhibits flowering by repressing ’SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1’ (196 aa)
EARLY FLOWERING IN SHORT DAYS; Histone methyltransferase involved in di and tri- methylation of ’Lys-36’ of histone H3 (H3K36me2 and H3K36me3). Binds to H3 already mono- or di-methylated on ’Lys-4’(H3K4me1 or H3K4me2), but not to H3K4me3. H3K4me and H3K36me represent specific tags for epigenetic transcriptional activation. Regulates positively FLC transcription to prevent early flowering transition. Required for flowering transition in response to vernalization and for the maintenance of FLC expression in late embryos, but dispensable for the initial reactivation in early embryos durin [...] (1805 aa)
SERRATED LEAVES AND EARLY FLOWERING; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Coodinates SWR1-C, FRI-C (FLC transcription activator complex), histone methyltransferase and general transcription factors. Represses flowering by positively regulating FLC and MAF4. Binds to the promoter region of FLC chromatin (171 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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