• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
AFH14 protein (Arabidopsis thaliana) - STRING interaction network
"AFH14" - Formin-like protein 14 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFH14Formin-like protein 14; Encodes the Type II Arabidopsis formin14. Interacts with microtubules and microfilaments to regulate cell division; Belongs to the formin-like family. Class-II subfamily (1230 aa)    
Predicted Functional Partners:
At5g55000
FH protein interacting protein FIP2; May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (298 aa)
     
   
  0.735
MAP18
Plasma membrane-associated cation-binding protein 2; Encodes a protein with seven repeated VEEKK motifs. RNAi and overexpression experiments suggest that the gene is not involved in cell division but might be consequential for cell shape of epidermal and cortical cells. The protein encoded by this gene binds to cortical microtubules and inhibits tubulin polymerization. Associates to the plasma membrane and interacts with calmodulin and phosphatidylinositol phosphates, indicating an involvement in cellular signal transduction. Expression is enhanced by abiotic and hormonal factors. Indu [...] (168 aa)
           
  0.699
AT3G14190
Protein PATRONUS 1; Required for the maintenance of centromeric cohesion during interkinesis, until meiosis II. Required for regular configuration and segregation of sister chromatids in meiosis II. Also required for centromere cohesion during meiosis I. Involved in spindle organization at the end of telophase I and in meiosis II. Required to prevent precocious release of pericentromeric cohesins during meiosis, but not for cohesion establishment and monopolar orientation of kinetochores at meiosis I. Involved also in somatic development. Regulates mitotic cell division and ploidy stab [...] (193 aa)
           
  0.669
RSW4
Encodes a separase (ESP), homologous to human and mouse separase protein. Separase is a capase family protease required for the release of sister chromatid cohesion during meiosis and mitosis. Arabidopsis separase contains a predicted 2Fe2S-ferredoxin domain that is not present in the proteins of other organisms. Also contains a putative EF-hand calcium binding domain. Mutant seeds exhibited embryo arrest at the globular stage. The endosperm also exhibited a weak titan-like phenotype. Transgenic plants expressing AESP RNA interference (RNAi) from the meiosis-specific DMC1 promoter exh [...] (2180 aa)
     
   
  0.588
ACT12
Actin-12; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the reproductive actins (377 aa)
       
 
  0.569
WYR
Contains the following InterPro domains- Inner centromere protein, ARK-binding region (InterPro-IPR005635); Has 1807 Blast hits to 1807 proteins in 277 species- Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source- NCBI BLink) (1826 aa)
     
   
  0.565
At1g34355
Forkhead-associated (FHA) domain-containing protein; Encodes PS1 (Parallel Spindle 1). Mutations in PS1 lead to diploid male spores, diploid pollen grains, and spontaneous triploid plants in the next generation. Female meiosis is not affected in the mutants (1477 aa)
     
   
  0.557
AT5G57460
Muniscin carboxy-terminal mu-like domain protein; Unknown protein; Its function is described as molecular_function unknown; Involved in biological_process unknown; Located in plasma membrane, chloroplast; Expressed in 23 plant structures; Expressed during 13 growth stages; Has 166 Blast hits to 166 proteins in 41 species- Archae - 0; Bacteria - 0; Metazoa - 112; Fungi - 4; Plants - 36; Viruses - 0; Other Eukaryotes - 14 (source- NCBI BLink); Belongs to the adaptor complexes medium subunit family (646 aa)
       
 
  0.551
ATK5
Kinesin-like protein KIN-14D; Kinesin that supports microtubule movement in an ATP- dependent manner and that functions as a minus-end directed motor as well as a plus-end tracking protein. During mitosis, is involved in early spindle assembly. Participates in the capture of antiparallel interpolar microtubules and helps in generating force to coalign microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily (790 aa)
     
 
  0.545
ARP2
Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. Involved in the control of cell morphogenesis in leaf epidermal pavement cells, root hairs, hypocotyls epidermal cells and trichomes, [...] (389 aa)
     
 
  0.519
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (10%) [HD]