STRINGSTRING
FRL2 protein (Arabidopsis thaliana) - STRING interaction network
"FRL2" - FRIGIDA like 2 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FRL2FRIGIDA like 2; Inactive FIRGIDA-like 2 protein (473 aa)    
Predicted Functional Partners:
MAF1
MADS AFFECTING FLOWERING 1; Probable transcription factor involved in the negative regulation of flowering time in both long and short days, probably through the photoperiodic and vernalization pathways. Prevents premature flowering (196 aa)
           
  0.709
AT2G22440
Uncharacterized protein (256 aa)
           
  0.679
VIN3
VERNALIZATION INSENSITIVE 3; Plays a central role in vernalization by mediating the initial transcriptional repression of the homeotic gene FLC, a floral repressor, after a cold treatment. However, due to its transient expression, it can not maintain repression of FLC, which is then maintained by Polycomb Group complexes containing VRN2 throughout development. Required to deacetylate histones on the FLC promoter. Together with VIL1, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e.g. chromatin modi [...] (620 aa)
           
  0.670
PIE1
Helicase SWR1; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Probable DNA-dependent ATPase. Not involved in the repression of FLC in gametophytes, but required for the reactivation of FLC in early embryos and for the maintenance of full activation of FLC in late embryos (2055 aa)
           
  0.670
VRN2
REDUCED VERNALIZATION RESPONSE 2; Polycomb group (PcG) protein. Plays a central role in vernalization by maintaining repressed the homeotic gene FLC, a floral repressor, after a cold treatment. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Associates co [...] (440 aa)
     
   
  0.658
HUA2
ENHANCER OF AG-4 2; Transcription factor that functions as repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP. Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA. Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression (PubMed-10198637, PubMed-12530963, PubMed-15659097). Acts as transcription regulator that controls anthocyanin accumul [...] (1392 aa)
     
   
  0.658
SUF4
Suppressor of FRIGIDA4; Sequence-specific DNA binding factor that recognizes the 5’-CCAAATTTTAAGTTT-3’ sequence. Recruites the FRI-C complex to the FLC promoter. Required for FRI-mediated FLC activation, but has no effect on the expression of MAF1, MAF2, MAF3, MAF5, UFC and CO. Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development (367 aa)
     
   
  0.643
FLC
FLOWERING LOCUS C; Putative transcription factor that seems to play a central role in the regulation of flowering time in the late- flowering phenotype by interacting with ’FRIGIDA’, the autonomous and the vernalization flowering pathways. Inhibits flowering by repressing ’SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1’ (196 aa)
           
  0.634
VRN1
REDUCED VERNALIZATION RESPONSE 1; Involved in the regulation of vernalization. Acts as transcriptional repressor of FLC, a major target of the vernalization pathway. Binds DNA in vitro in a non-sequence- specific manner (341 aa)
     
   
  0.618
VIP4
Leo1-like family protein; Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 ’Lys-4’ (H3K4me3) (PubMed-20363855). Involved in regulation of flowering time. Required for the expression of the flowering repressor and MADS box gene FLC (PubMed-12207655). Involved in the control of seed dormancy and germination (PubMed-21799800) (625 aa)
           
  0.603
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (14%) [HD]