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AT1G31910 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G31910" - Phosphomevalonate kinase, peroxisomal in Arabidopsis thaliana
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second shell of interactors
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proteins of unknown 3D structure
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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AT1G31910Phosphomevalonate kinase, peroxisomal; GHMP kinase family protein; Its function is described as kinase activity, ATP binding; Involved in phosphorylation; Expressed in 24 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- Phosphomevalonate kinase, eukaryotic (InterPro-IPR005916), Phosphomevalonate kinase, ERG8 (InterPro-IPR016005), Ribosomal protein S5 domain 2-type fold (InterPro-IPR020568), GHMP kinase (InterPro-IPR006204), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro-IPR014721), GHMP kinase, C-terminal (InterPro-IPR013750); [...] (505 aa)    
Predicted Functional Partners:
MK
Encodes a protein with mevalonate kinase activity involved in the mevalonate pathway; Belongs to the GHMP kinase family. Mevalonate kinase subfamily (378 aa)
     
 
  0.999
MVD1
Diphosphomevalonate decarboxylase MVD1, peroxisomal; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5- diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5- phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP. Can complement a yeast mutant defective in MVD activity (412 aa)
   
 
  0.997
AT3G54250
Diphosphomevalonate decarboxylase MVD2, peroxisomal; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5-diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP; Belongs to the diphosphomevalonate decarboxylase family (419 aa)
   
 
  0.991
HMGS
Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation (461 aa)
     
   
  0.990
PRP40C
Pre-mRNA-processing protein 40C; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. I [...] (835 aa)
       
      0.965
IPP1
Isopentenyl-diphosphate Delta-isomerase I, chloroplastic; Encodes a protein with isopentenyl diphosphate-dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway; Belongs to the IPP isomerase type 1 family (291 aa)
           
  0.959
HMG1
Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine (642 aa)
           
  0.939
ISPD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis (302 aa)
           
  0.921
DXR
1-Deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) catalyzes the first committed step of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. In Arabidopsis, DXR is encoded by a single-copy gene. Arabidopsis DXR is targeted to plastids and localizes into chloroplasts of leaf cells. DXR knockout or strongly silenced lines have a seedling lethal, albino phenotype. Transgenic, partially silenced lines expressing 35S-DXR have a variegated phenotype (497 aa)
           
  0.915
SQS1
Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate- presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway (410 aa)
     
 
  0.912
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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