STRINGSTRING
LOL1 protein (Arabidopsis thaliana) - STRING interaction network
"LOL1" - Lsd one like 1 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOL1Lsd one like 1; Positive regulator of reactive oxygen-induced cell death. May be involved in the repression of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death (187 aa)    
Predicted Functional Partners:
AT3G47650
DnaJ/Hsp40 cysteine-rich domain superfamily protein; Its function is described as unfolded protein binding, heat shock protein binding; Involved in protein folding; Located in chloroplast; Expressed in 23 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Heat shock protein DnaJ, cysteine-rich domain (InterPro-IPR001305); Has 88 Blast hits to 88 proteins in 28 species- Archae - 0; Bacteria - 7; Metazoa - 0; Fungi - 0; Plants - 70; Viruses - 0; Other Eukaryotes - 11 (source- NCBI BLink) (136 aa)
     
        0.916
PMZ
Zinc finger AN1 domain-containing stress-associated protein 12; May be involved in environmental stress response (186 aa)
           
  0.815
AT3G56820
AT3g56820/T8M16_150; Unknown protein; Has 34 Blast hits to 34 proteins in 13 species- Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 27; Viruses - 0; Other Eukaryotes - 7 (source- NCBI BLink) (220 aa)
           
  0.762
MC9
Metacaspase-9; Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Required for proteolytic processing of GRI; Belongs to the peptidase C14B family (325 aa)
           
  0.752
NFXL1
NF-X1-type zinc finger protein NFXL1; Mediates E2-dependent ubiquitination (By similarity). Confers resistance to osmotic stress such as high salinity. Promotes H(2)O(2) production. Negative regulator of some defense- related genes via an salicylic acid (SA)-dependent signaling pathway. Confers susceptibility to the compatible phytopathogen Pseudomonas syringae pv. tomato strain DC3000 (Pst DC3000). Mediates resistance to type A trichothecenes (phytotoxins produced by phytopathogenic fungi); Belongs to the NFX1 family (1188 aa)
           
  0.740
MC3
Metacaspase-3; Metacaspase 3 (MC3); Its function is described as cysteine-type endopeptidase activity; Involved in proteolysis; Expressed in 20 plant structures; Expressed during 10 growth stages; Contains the following InterPro domains- Peptidase C14, caspase catalytic (InterPro-IPR011600); BEST Arabidopsis thaliana protein match is- metacaspase 1 (TAIR-AT1G02170.1); Has 1807 Blast hits to 1807 proteins in 277 species- Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source- NCBI BLink) (362 aa)
           
  0.682
ADA2B
Transcriptional adapter ADA2b; Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity). ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region. Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (487 aa)
           
  0.647
ADA2A
Transcriptional adapter ADA2a; Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity). ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region (555 aa)
           
  0.647
CH1
Pheophorbide a oxygenase family protein with Rieske [2Fe-2S] domain; Encodes chlorophyllide <i>a</i> oxygenase which converts chlorophyllide <i>a</i> to chlorophyllide <i>b</i> by catalyzing two successive hydroxylations at the 7-methyl group of chlorophyllide <i>a</i> . Mutants are deficient in pigments that associate with thylakoid membrane proteins, lacking chlorophyll <i>b</i> and light-harvesting proteins of photosystem II. The protein was shown through cross-linking experiments to interact with Toc75, Toc34, Tic40, Tic20 and Tic22 (536 aa)
     
   
  0.611
SPL8
Squamosa promoter-binding-like protein 8; Trans-acting factor that binds specifically to the consensus nucleotide sequence 5’-TNCGTACAA-3’. Binds specifically to the 5’-GTAC-3’ core sequence. Involved in development and floral organogenesis. Required for ovule differentiation, pollen production, filament elongation, seed formation and siliques elongation. Also seems to play a role in the formation of trichomes on sepals. May positively modulate gibberellin (GA) signaling in flower (333 aa)
           
  0.587
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (11%) [HD]