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EPF2 protein (Arabidopsis thaliana) - STRING interaction network
"EPF2" - Protein EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis thaliana
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textmining
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EPF2Protein EPIDERMAL PATTERNING FACTOR 2; Controls stomatal patterning. Regulates the number of cells that enter, and remain in, the stomatal lineage by inhibiting protodermal cells from adopting the meristemoid mother cell (MMC) fate in a non-cell-autonomous manner. Mediates stomatal development inhibition. MEPF2- mobile signal controlling stomatal development in a non-cell-autonomous manner. Uses ERECTA as major receptor. Inactivated by cleavage by CRSP (AC Q9LNU1). May act by competing with somatogen (AC Q9SV72) for the same receptor, TMM (AC Q9SSD1) (120 aa)    
Predicted Functional Partners:
ERL1
LRR receptor-like serine/threonine-protein kinase ERL1; Encodes a receptor-like kinase that, together with ER and ERL2 governs the initial decision of protodermal cells to either divide proliferatively to produce pavement cells or divide asymmetrically to generate stomatal complexes. It is important for maintaining stomatal stem cell activity and preventing terminal differentiation of the meristemoid into the guard mother cell. Along with erl2 functionally compensates for loss of erecta during integument development; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family (966 aa)
     
  0.995
TMM
Leucine-rich repeat (LRR) family protein; Promotes cell fate progression in stomatal development. In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids. In stems, promotes the conversion of meristemoids into guard mother cells (GMC). Modulates probably the activity of the ligand- receptor pairs EPF2-ERECTA and EPF1-ERL1 via heterodimerization (496 aa)
     
 
  0.992
ERL2
LRR receptor-like serine/threonine-protein kinase ERL2; Encodes a receptor-like kinase that, together with ER and ERL1 governs the initial decision of protodermal cells to either divide proliferatively to produce pavement cells or divide asymmetrically to generate stomatal complexes. It is also important for maintaining stomatal stem cell activity and preventing terminal differentiation of the meristemoid into the guard mother cell. When heterozygous in an er/erl1 null background, plants are female sterile due to cell division defect in the integuments (967 aa)
     
 
  0.981
STOMAGEN
EPIDERMAL PATTERNING FACTOR-like protein 9; Encodes a cysteine-rich peptide, a secretory factor that is produced in the mesophyll cells and acts on the epidermis to increase stomatal formation. Its mature form is a 45-aa peptide with three intramolecular disulfide bonds. It is proposed that STOMAGEN increases stomatal number by competing with two negative regulators of stomatal density, EPF1 and EPF2, possibly through direct interaction with the receptor-like protein TMM (102 aa)
     
   
  0.970
CHAL
EPIDERMAL PATTERNING FACTOR-like protein 6; Acts primarily as positive regulator of inflorescence growth. Endodermal expression is sufficient for proper inflorescence architecture. Redundantly involved with EPFL4 in procambial development regulation. Acts also as tissue-specific regulator of epidermal pattern. Controls stomatal patterning by repressing stomatal production. TMM (AC Q9SSD1) functions to dampen or block CHAL signaling. Not processed by SDD1 (AC O64495). Acts as growth-regulatory ligand for ERECTA family receptors; Belongs to the plant cysteine rich small secretory peptide [...] (230 aa)
     
   
  0.952
SPCH
Encodes a basic helix-loop-helix (bHLH) transcription factor that is necessary and sufficient for the asymmetric divisions that establish the stomatal lineage in Arabidopsis thaliana. Expression of SPCH in young epidermal cells allows these cells to make asymmetric divisions. SPCH is a substrate of a kinase MPK3 and MPK6 (364 aa)
     
   
  0.927
TE1
LRR receptor-like serine/threonine-protein kinase ERECTA; Receptor kinase that, together with ERL1 and ERL2, regulates aerial architecture, including inflorescence (e.g. shoot apical meristem-originating organ shape, elongation of the internode and pedicels, and adaxial-abaxial polarity), and stomatal patterning (e.g. density and clustering), probably by tuning cell division and expansion. Redundantly involved with ERL1 in procambial development regulation. Forms a functional ligand- receptor pair with EPF2 (AC Q8LC53). Modulates plant transpiration efficiency by controlling stomatal d [...] (976 aa)
     
  0.916
CLL2
EPIDERMAL PATTERNING FACTOR-like protein 4; Acts primarily as positive regulator of inflorescence growth. Endodermal expression is sufficient for proper inflorescence architecture. Redundantly involved with EPFL6 in procambial development regulation. Controls stomatal patterning. Mediates stomatal development inhibition. TMM (AC Q9SSD1) functions to dampen or block CLL2 signaling. Acts as growth-regulatory ligand for ERECTA family receptors (109 aa)
     
   
  0.909
MUTE
Basic helix-loop-helix (bHLH) DNA-binding superfamily protein; Transcription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata (202 aa)
     
   
  0.884
SDD1
Subtilisin-like protease SBT1.2; Serine protease involved in the negative regulation of stomatal density and distribution. Not active on EPFL6 (AC Q1PEY6). Positive regulator of water use efficiency (WUE) (775 aa)
     
   
  0.884
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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