| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AT1G34380 | AT2G21550 | AT1G34380.2 | AT2G21550.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | 0.898 |
| AT1G34380 | ERCC1 | AT1G34380.2 | AT3G05210.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] | 0.687 |
| AT1G34380 | MRE11 | AT1G34380.2 | AT5G54260.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Double-strand break repair protein MRE11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand- specific 3’-5’ exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family | 0.651 |
| AT1G34380 | PCNA1 | AT1G34380.2 | AT1G07370.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Proliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand; Belongs to the PCNA family | 0.803 |
| AT1G34380 | PCNA2 | AT1G34380.2 | AT2G29570.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (By similarity). May be involved in UV resistance; Belongs to the PCNA family | 0.803 |
| AT1G34380 | RNR1 | AT1G34380.2 | AT2G21790.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. Ribonucleotide reductase (RNR) complex function is essential for efficient organellar DNA degradation in pollen. Involved in chloroplast division | 0.719 |
| AT1G34380 | THY-1 | AT1G34380.2 | AT2G16370.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Bifunctional dihydrofolate reductase-thymidylate synthase 1; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family | 0.898 |
| AT1G34380 | THY-2 | AT1G34380.2 | AT4G34570.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Bifunctional dihydrofolate reductase-thymidylate synthase 2; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family | 0.898 |
| AT1G34380 | XPB1 | AT1G34380.2 | AT5G41370.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Homolog of xeroderma pigmentosum complementation group B 1; Encodes XPB1, a DNA repair protein and transcription factor. Arabidopsis thaliana has duplicated XPB gene (AtXPB1 and AtXPB2, with high similarity to each other). XPB proteins are involved in both DNA repair and transcription, they are component of the transcription factor IIH (TFIIH) and are responsible for DNA helicase activity during nucleotide (nt) excision repair (NER). Complementation assays in yeast rad25 mutant strains suggest the involvement of AtXPB2 in DNA repair. Although both genes are expressed in a constitutive [...] | 0.646 |
| AT1G34380 | XPB2 | AT1G34380.2 | AT5G41360.1 | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | Homolog of Xeroderma pigmentosum complementation group B 2; Encodes XPB2, a DNA repair protein and transcription factor. Arabidopsis thaliana has duplicated XPB gene (AtXPB1 and AtXPB2, with high similarity to each other). XPB proteins are involved in both DNA repair and transcription, they are component of the transcription factor IIH (TFIIH) and are responsible for DNA helicase activity during nucleotide (nt) excision repair (NER). Complementation assays in yeast rad25 mutant strains suggest the involvement of AtXPB2 in DNA repair. Although both genes are expressed in a constitutive [...] | 0.646 |
| AT2G21550 | AT1G34380 | AT2G21550.1 | AT1G34380.2 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | 0.898 |
| AT2G21550 | ERCC1 | AT2G21550.1 | AT3G05210.1 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] | 0.536 |
| AT2G21550 | PCNA1 | AT2G21550.1 | AT1G07370.1 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | Proliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand; Belongs to the PCNA family | 0.972 |
| AT2G21550 | PCNA2 | AT2G21550.1 | AT2G29570.1 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (By similarity). May be involved in UV resistance; Belongs to the PCNA family | 0.972 |
| AT2G21550 | RNR1 | AT2G21550.1 | AT2G21790.1 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. Ribonucleotide reductase (RNR) complex function is essential for efficient organellar DNA degradation in pollen. Involved in chloroplast division | 0.976 |
| AT2G21550 | THY-1 | AT2G21550.1 | AT2G16370.1 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | Bifunctional dihydrofolate reductase-thymidylate synthase 1; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family | 0.933 |
| AT2G21550 | THY-2 | AT2G21550.1 | AT4G34570.1 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | Bifunctional dihydrofolate reductase-thymidylate synthase 2; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family | 0.933 |
| ERCC1 | AT1G34380 | AT3G05210.1 | AT1G34380.2 | Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] | 5’-3’ exonuclease family protein; Its function is described as 5’-3’ exonuclease activity, DNA binding, catalytic activity; Involved in biological_process unknown; Located in chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- 5'-3' exonuclease, SAM-fold domain (InterPro-IPR020047), 5'-3' exonuclease, C-terminal subdomain (InterPro-IPR020045), 5'-3' exonuclease, N-terminal resolvase-like domain (InterPro-IPR020046); BEST Arabidopsis thaliana protein match is- 5’-3’ exonuclease family pr [...] | 0.687 |
| ERCC1 | AT2G21550 | AT3G05210.1 | AT2G21550.1 | Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism | 0.536 |
| ERCC1 | MRE11 | AT3G05210.1 | AT5G54260.1 | Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] | Double-strand break repair protein MRE11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand- specific 3’-5’ exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family | 0.740 |
