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FANCM protein (Arabidopsis thaliana) - STRING interaction network
"FANCM" - DEAD-box ATP-dependent RNA helicase FANCM in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
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Gene Fusion
FANCMDEAD-box ATP-dependent RNA helicase FANCM; Involved in ordered homologous recombination (HR) events in somatic and meiotic cells. Involved in the suppression of spontaneous HR events in somatic cells. Has an opposite function to the DNA binding cofactor MHF1 which promotes spontaneous HR. Functions in replicative repair independently of MHF1 and in a parallel pathway to the endonuclease MUS81. Acts in the same pathway as the two DNA-binding cofactors MHF1 and MHF2 to restrain class II meiotic crossover (CO), and acts exclusively with MHF1 and MHF2 during meiosis to repair DNA interstra [...] (1390 aa)    
Predicted Functional Partners:
Restriction endonuclease, type II-like superfamily protein; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5’-end at the branch nick. Typical substrates include 3’- flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Media [...] (659 aa)
ATP-dependent DNA helicase Q-like 4A; 3’-5’ DNA helicase involved in DNA repair. Required for the maintenance of genome stability by modulation of the DNA damage response and repression of crossovers. Confers resistance to genotoxic stress. Suppresses spontaneous homologous recombination (HR) events in somatic cells together with its partners RMI1 and TOP3A. Contributes to the maintenance of chromosome integrity during meiosis. Involved in the removal of telomeric bridges that appear to arise during meiotic recombination. Required to resolve or dissolve MSH4-dependent telomeric associa [...] (1188 aa)
Nucleotide repair protein, putative; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5’ to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA- damage sensitive cell-cycle checkpoint during the [...] (410 aa)
ATP-dependent DNA helicase Q-like 4B; 3’-5’ DNA helicase that may play a role in the repair of DNA (By similarity). Required to promote but not to suppress crossovers (1150 aa)
Contains the following InterPro domains- Domain of unknown function DUF1767 (InterPro-IPR013894); BEST Arabidopsis thaliana protein match is- Domain of unknown function (DUF1767) (TAIR-AT5G63540.1); Has 30201 Blast hits to 17322 proteins in 780 species- Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source- NCBI BLink) (443 aa)
DNA mismatch repair protein MSH5; Encodes MSH5, a homologue of the MutS-homolog family of genes required for normal levels of recombination in budding yeast, mouse and Caenorhabditis elegans. Involved in meiotic recombination. Required for the formation of Class I interference-sensitive crossovers. Transcripts of AtMSH5 are specific to reproductive tissues and expression of the protein is abundant during prophase I of meiosis. Involved in meiotic recombination. Required for the formation of Class I interference-sensitive crossovers; Belongs to the DNA mismatch repair MutS family (807 aa)
Zinc ion binding; Its function is described as zinc ion binding; Involved in biological_process unknown; Located in cellular_component unknown; Contains the following InterPro domains- Zinc finger, RING-type (InterPro-IPR001841), Fanconi anemia complex, subunit FancL, WD-repeat region (InterPro-IPR019162); Has 164 Blast hits to 163 proteins in 67 species- Archae - 0; Bacteria - 0; Metazoa - 111; Fungi - 0; Plants - 35; Viruses - 0; Other Eukaryotes - 18 (source- NCBI BLink) (300 aa)
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Limits class II meiotic crossover (CO) formation by regulating the invasion step of meiotic HR. May counteract DMC1 and RAD51-mediated inter-homolog strand invasion to limit CO formation. Functions independently of FANCM; Belongs to the AAA ATPase family (476 aa)
DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. [...] (926 aa)
Histone superfamily protein; Involved in the promotion of spontaneous somatic homologous recombination (HR) events, which is opposite to the function of FANCM in ordered HR. Only FANCM is essential for replicative repair in the absence of the endonuclease MUS81. Acts in the same pathway as FANCM to restrain class II meiotic crossing over (CO), and acts with FANCM during meiosis to repair interstrand cross-links (ICLs). This common pathway between MHF1 and FANCM is in parallel to the pathway that involves the RECQ4A helicase (242 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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