• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
ACC2 protein (Arabidopsis thaliana) - STRING interaction network
"ACC2" - Acetyl-CoA carboxylase 2 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACC2Acetyl-CoA carboxylase 2; Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation (2355 aa)    
Predicted Functional Partners:
BCCP2
Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA (255 aa)
   
  0.998
CAC1
Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA (280 aa)
   
  0.998
EMB3147
Catalytics;transferases;[acyl-carrier-protein] S-malonyltransferases;binding; Its function is described as binding, transferase activity, [acyl-carrier-protein] S-malonyltransferase activity, catalytic activity; Involved in fatty acid biosynthetic process, metabolic process; Located in chloroplast, chloroplast stroma; Expressed in 23 plant structures; Expressed during 14 growth stages; Contains the following InterPro domains- Acyl transferase/acyl hydrolase/lysophospholipase (InterPro-IPR016035), Malonyl CoA-acyl carrier protein transacylase (InterPro-IPR004410), Acyl transferase domai [...] (393 aa)
   
  0.995
HCS1
Biotin--protein ligase 1, chloroplastic; Plays a major role in biotin-dependent carboxylase biotinylation. Catalyzes the addition of biotin to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase and can also biotinylate methylcrotonyl-CoA carboxylase. Is responsible for most, if not all, biotin--protein ligase activity in Arabidopsis. Is essential for plant viability and required for ovule development (367 aa)
   
  0.995
HCS2
Holocarboxylase synthetase 2; Seems to have no or limited implication in biotin- dependent carboxylase biotinylation in planta (329 aa)
   
  0.995
CAC3
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity); Belongs to the AccA family (769 aa)
   
  0.983
ACLA-3
ATP-citrate synthase alpha chain protein 3; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known anima [...] (424 aa)
     
 
  0.971
T3P18.20
3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. KAS III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities (By similarity); Belongs to the FabH family (404 aa)
   
 
  0.965
ACS
Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; Encodes a plastidic acetyl-coA synthetase. This enzyme plays a role in converting acetate to acetyl-coA in the plastids. It does not appear to be a major contributor to fatty acid biosynthesis based on mutant phenotypes. The enzyme seems to act as a monomer and may play an important role in preventing the toxic accumulation of fermentation products including acetaldehyde, acetate, and ethanol. It participates in the pyruvate dehydrogenase bypass pathway; Belongs to the ATP-dependent AMP-binding enzyme family (743 aa)
   
  0.956
MLS
Malate synthase; Does not seem to be essential for lipid utilization and gluconeogenesis in seedlings; Belongs to the malate synthase family (562 aa)
         
  0.924
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (9%) [HD]