Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Cysteine proteinases superfamily protein; Its function is described as cysteine-type peptidase activity; Involved in proteolysis; Located in cellular_component unknown; Contains the following InterPro domains- Peptidase C48, SUMO/Sentrin/Ubl1 (InterPro-IPR003653); BEST Arabidopsis thaliana protein match is- Ulp1 protease family protein (TAIR-AT5G45570.1); Has 315 Blast hits to 281 proteins in 53 species- Archae - 2; Bacteria - 21; Metazoa - 20; Fungi - 17; Plants - 180; Viruses - 0; Other Eukaryotes - 75 (source- NCBI BLink) (611 aa)
Sorry, there are no predicted associations at the current settings.
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NCBI taxonomy Id: 3702 Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress