STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
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Experiments
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Textmining
[Homology]
Score
ALDH3H1Aldehyde dehydrogenase family 3 member H1; Involved in oxidative stress tolerance by detoxifying reactive aldehydes derived from lipid peroxidation. Medium- to long-chain saturated aldehydes are preferred substrates, while the short-chain aldehyde propanal is a weak substrate. Is strictely NAD(+) specific (484 aa)    
Predicted Functional Partners:
ACS
Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; Encodes a plastidic acetyl-coA synthetase. This enzyme plays a role in converting acetate to acetyl-coA in the plastids. It does not appear to be a major contributor to fatty acid biosynthesis based on mutant phenotypes. The enzyme seems to act as a monomer and may play an important role in preventing the toxic accumulation of fermentation products including acetaldehyde, acetate, and ethanol. It participates in the pyruvate dehydrogenase bypass pathway; Belongs to the ATP-dependent AMP-binding enzyme family
  
 0.966
AT1G80380
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Catalyzes the concluding reaction of the photorespiratory C2 cycle, an indispensable ancillary metabolic pathway to the photosynthetic C3 cycle that enables land plants to grow in an oxygen-containing atmosphere
     
 0.958
PAO1
Polyamine oxidase 1; Flavoenzyme that catalyzes the oxidation of the secondary amino group of spermine, norspermine and N(1)- acetylspermine. Substrate preference is norspermine > spermine > N(1)-acetylspermine. No activity detected when putrescine, spermidine or N(1)-acetylspermidine are used as substrates. Plays an important role in the regulation of polyamine intracellular concentration; Belongs to the flavin monoamine oxidase family
     
 0.956
FAO3
Long-chain-alcohol oxidase FAO3; Long-chain fatty alcohol oxidase involved in the omega- oxidation pathway of lipid degradation; Belongs to the GMC oxidoreductase family
  
 
 0.947
ALDH6B2
Malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase; Arabidopsis thaliana methylmalonate-semialdehyde dehydrogenase
  
0.944
AKR4C10
NAD(P)-linked oxidoreductase superfamily protein; Oxidoreductase that may act on a broad range of substrates such as ketosteroids, aldehydes, ketones and sugars
   
 0.944
BETA-UP
Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N- carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3- ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta- alanine, ammonia and carbon dioxide. Involved in the recycling of nitrogen from nucleobases to general nitrogen metabolism
   
 
 0.940
AT5G24760
GroES-like zinc-binding dehydrogenase family protein; Its function is described as oxidoreductase activity, zinc ion binding; Involved in oxidation reduction; Located in chloroplast; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains: GroES-like (InterPro:IPR011032), Polyketide synthase, enoylreductase (InterPro:IPR020843), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Alcohol dehydrogenase, zinc-containing, conserved site (InterPro:IPR002328), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenas [...]
  
 0.938
AAE13
AMP-dependent synthetase and ligase family protein; Malonate--CoA ligase that catalyzes the formation of malonyl-CoA directly from malonate and CoA. May be required for the detoxification of malonate; Belongs to the ATP-dependent AMP-binding enzyme family
  
 0.934
HOT5
S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase; GroES-like zinc-binding dehydrogenase family protein; Encodes a glutathione-dependent formaldehyde dehydrogenase (also known as class III type alcohol dehydrogenase) reduces S-nitrosoglutathione (GSNO), the condensation product of glutathione and NO, that is a naturally occurring NO reservoir and also a reactive nitrogen intermediate. Gene expression is reduced by wounding and induced by salicylic acid. Is required for the acclimation of plants to high temperature and for fertility
  
 0.934
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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