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STRINGSTRING
SERPIN1 protein (Arabidopsis thaliana) - STRING interaction network
"SERPIN1" - Serine protease inhibitor in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SERPIN1Serine protease inhibitor (SERPIN) family protein; Inhibits metacaspase-9 (MC9) cysteine protease. Functions through cleavage of its reactive center loop and covalent binding to MC9. Involved in the control of elicitor- stimulated programmed cell death (PCD). During infection by the necrotrophic fungal pathogen Botrytis cinerea, functions to protect cells by limiting the PCD-promoting protease RD21A activity that is released from the ER body or vacuole to the cytoplasm. Involved in the control of water stress-induced cell death by limiting the pro-death protease RD21A activity that is [...] (391 aa)    
Predicted Functional Partners:
RD21A
Granulin repeat cysteine protease family protein; Cysteine protease that plays a role in immunity, senescence, and biotic and abiotic stresses (Probable). Involved in immunity against the necrotrophic fungal pathogen Botrytis cinerea. Involved in elicitor-stimulated programmed cell death (PCD). During infection by the necrotrophic fungal pathogen Botrytis cinerea, functions as PCD-promoting protease that is released from the ER body or vacuole to the cytoplasm. Accumulates in endoplasmic reticulum- derived bodies in epidermal cells and may participate in cell death in stressed or injur [...] (462 aa)
       
 
  0.993
MC9
Metacaspase-9; Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Required for proteolytic processing of GRI; Belongs to the peptidase C14B family (325 aa)
           
  0.953
PER1
1-cysteine peroxiredoxin 1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (216 aa)
       
  0.941
PBB1
N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (273 aa)
       
  0.940
PBB2
20S proteasome beta subunit PBB2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (274 aa)
       
  0.936
GDI
GDP dissociation inhibitor family protein / Rab GTPase activator family protein; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP (445 aa)
         
  0.934
ALP
Thiol protease aleurain; May play a role in proteolysis leading to mobilization of nitrogen during senescence and starvation (361 aa)
       
  0.931
GDI2
Guanosine nucleotide diphosphate dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP (444 aa)
         
  0.924
GDI1
Guanosine nucleotide diphosphate dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family (445 aa)
         
  0.924
AARE
Acylamino-acid-releasing enzyme; Catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. Can degrade the glycated RuBisCO (ribulose-1,5-bisphoshate carboxylase/oxygenase) protein but not the native protein. May be involved in the elimination of glycated proteins. Plays a homeostatic role in sustaining the cytoplasmic antioxidative system. May contribute to the elimination of the oxidized proteins in the cytoplasm (764 aa)
         
  0.924
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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