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ATE2F2 protein (Arabidopsis thaliana) - STRING interaction network
"ATE2F2" - E2F-5-like protein AtE2F2 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ATE2F2E2F-5-like protein AtE2F2; Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex (396 aa)    
Predicted Functional Partners:
DPB
Transcription factor DP; Involved in the regulation of the G1/S transition. Increases the DNA binding activity of E2F proteins after heterodimerization. The complex DPB/E2FC restricts cell division and lateral root initiation and may function as a negative regulator of E2F-regulated genes. The interaction with SKP2A is controlled by auxin (385 aa)
     
  0.999
RBR1
Retinoblastoma-related 1; Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate (PubMed-18064404, PubMed-21444209). Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation (PubMed-22307083). Plays a central role in the mechanism controlling meristem cell differentia [...] (1013 aa)
     
  0.999
DPA
Core cell cycle genes; Involved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specic genes (292 aa)
     
  0.999
CYC3B
cyclin-A2-2 (436 aa)
     
  0.995
CDC2
Cell division control 2; Involved in the control of the cell cycle. Essential for both G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis (294 aa)
     
  0.993
CYCA2;3
CYCLIN A2;3; Negatively regulates endocycles and acts as a regulator of ploidy levels in endoreduplication (450 aa)
     
  0.988
CYCA3;1
Cyclin A3-1 (355 aa)
     
  0.984
CYCA3;2
cyclin-A3-2 (372 aa)
     
  0.982
CYCA2;1
Cyclin a2;1; May negatively regulate endocycles and act as a regulator of ploidy levels in endoreduplication (437 aa)
     
  0.981
CYCA3;4
CYCLIN A3;4 (370 aa)
     
  0.980
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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