• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
ATE2F2 protein (Arabidopsis thaliana) - STRING interaction network
"ATE2F2" - Winged-helix DNA-binding transcription factor family protein in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATE2F2Winged-helix DNA-binding transcription factor family protein; Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway. AtE2Fc is regulated by a balance between gene expression and ubiquitin-proteasome proteolysis. AtE2Fc might play a role in cell division and during the transition from skotomorphogenesis to photomorphogenesis. E2Fc has been shown to interact with DPB in its nonphosphorylated form; when E2Fc is phosphorylated, the formation of the E2Fc/DPB heterodimer is lost; Belongs to the E2F/DP family (396 aa)    
Predicted Functional Partners:
DPB
Transcription factor-like protein DPB; Involved in the regulation of the G1/S transition. Increases the DNA binding activity of E2F proteins after heterodimerization. The complex DPB/E2FC restricts cell division and lateral root initiation and may function as a negative regulator of E2F-regulated genes. The interaction with SKP2A is controlled by auxin (385 aa)
     
  0.999
RBR1
Retinoblastoma-related protein 1; Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate. Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation. Plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate m [...] (1013 aa)
     
  0.999
DPA
Transcription factor-like protein DPA; Involved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specific genes; Belongs to the E2F/DP family (292 aa)
     
  0.999
CDC2
A-type cyclin-dependent kinase. Together with its specific inhibitor, the Kip-related protein, KRP2 they regulate the mitosis-to-endocycle transition during leaf development. Dominant negative mutations abolish cell division. Loss of function phenotype has reduced fertility with failure to transmit via pollen. Pollen development is arrested at the second mitotic division. Expression is regulated by environmental and chemical signals. Part of the promoter is responsible for expression in trichomes. Functions as a positive regulator of cell proliferation during development of the male [...] (294 aa)
     
  0.989
CYC3B
Mitotic-like cyclin 3B from Arabidopsis; Mitotic-like cyclin, core cell cycle gene that is expressed only in roots (RT_PCR), portions with mitotic activity only (whole mount in situ) (436 aa)
     
  0.986
CYCA1;1
Cyclin A1;1 (CYCA1;1); Contains the following InterPro domains- Cyclin, C-terminal (InterPro-IPR004367), Cyclin (InterPro-IPR006670), G2/mitotic-specific cyclin A (InterPro-IPR015453), Cyclin-like (InterPro-IPR011028), Cyclin-related (InterPro-IPR013763), Cyclin, N-terminal (InterPro-IPR006671), Cyclin, A/B/D/E (InterPro-IPR014400); BEST Arabidopsis thaliana protein match is- CYCLIN A1;2 (TAIR-AT1G77390.1); Has 4548 Blast hits to 4417 proteins in 376 species- Archae - 0; Bacteria - 4; Metazoa - 1999; Fungi - 561; Plants - 1168; Viruses - 34; Other Eukaryotes - 782 (source- NCBI BLink) (460 aa)
     
  0.976
CYCA3;1
Putative cyclin-A3-1; Cyclin A3;1 (CYCA3;1); Its function is described as cyclin-dependent protein kinase regulator activity; Involved in regulation of cell cycle; Located in nucleus; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Cyclin, C-terminal (InterPro-IPR004367), Cyclin (InterPro-IPR006670), G2/mitotic-specific cyclin A (InterPro-IPR015453), Cyclin-like (InterPro-IPR011028), Cyclin-related (InterPro-IPR013763), Cyclin, N-terminal (InterPro-IPR006671), Cyclin, A/B/D/E (InterPro-IPR014400); BEST Arabidopsis thaliana p [...] (355 aa)
     
  0.974
CYCA2;3
A2-type cyclin. Negatively regulates endocycles and acts as a key regulator of ploidy levels in Arabidopsis endoreduplication. Interacts physically with CDKA;1. Expressed preferentially in trichomes and young developing tissues (450 aa)
     
  0.970
CYCA3;2
Cyclin-dependent protein kinase 3;2 (CYCA3;2); Contains the following InterPro domains- Cyclin, C-terminal (InterPro-IPR004367), Cyclin (InterPro-IPR006670), G2/mitotic-specific cyclin A (InterPro-IPR015453), Cyclin-like (InterPro-IPR011028), Cyclin-related (InterPro-IPR013763), Cyclin, N-terminal (InterPro-IPR006671), Cyclin, A/B/D/E (InterPro-IPR014400); BEST Arabidopsis thaliana protein match is- CYCLIN A3;4 (TAIR-AT1G47230.1); Has 4323 Blast hits to 4316 proteins in 367 species- Archae - 0; Bacteria - 0; Metazoa - 1987; Fungi - 532; Plants - 1111; Viruses - 34; Other Eukaryotes - 6 [...] (372 aa)
     
  0.964
CYCA2;1
Cyclin-A2-1; May negatively regulate endocycles and act as a regulator of ploidy levels in endoreduplication; Belongs to the cyclin family. Cyclin AB subfamily (437 aa)
     
  0.959
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (9%) [HD]