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AT1G48360 protein (Arabidopsis thaliana) - STRING interaction network
"AT1G48360" - Fanconi-associated nuclease 1-like protein in Arabidopsis thaliana
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AT1G48360Fanconi-associated nuclease 1-like protein; Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5’-3’ exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (891 aa)    
Predicted Functional Partners:
MUS81
MMS AND UV SENSITIVE 81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5’-end at the branch nick. Typical substrates include 3’- flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombinati [...] (659 aa)
     
 
  0.937
FANCM
Fanconi anemia group M protein (1390 aa)
     
   
  0.874
RAD5
DNA/RNA helicase protein RAD5; Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for DNA repair (By similarity) (1029 aa)
     
   
  0.856
RECQ4A
ATP-dependent DNA helicase Q-like 4A; 3’-5’ DNA helicase that may play a role in the repair of DNA. Required for maintenance of genome stability by modulation of the DNA damage response and repression of crossovers. Confers resistance to genotoxic stress (1188 aa)
     
 
  0.718
PMS1
POSTMEIOTIC SEGREGATION 1; Required for DNA mismatch repair (MMR), correcting base- base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stabil [...] (923 aa)
     
 
  0.676
AT4G14970
Fanconi anemia group D2 protein (1489 aa)
     
  0.614
AT5G49110
Fanconi anemia group I protein (1470 aa)
     
  0.600
AT1G79950
RAD3-like DNA-binding helicase protein (1040 aa)
   
   
  0.587
SMC5
Structural maintenance of chromosomes 5; Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids (1053 aa)
     
        0.514
HEB1
ARM repeat superfamily protein (1203 aa)
     
        0.492
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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