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RHL1 protein (Arabidopsis thaliana) - STRING interaction network
"RHL1" - Encodes a novel nuclear protein required for root hair initiation and ploidy-dependent cell growth. Its sequence has similarity to the C-terminal domain of mammalian DNA topo IIalpha. Shows in vitro DNA binding activity and is likely to be part of the topo VI complex by binding to subunit A in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RHL1Encodes a novel nuclear protein required for root hair initiation and ploidy-dependent cell growth. Its sequence has similarity to the C-terminal domain of mammalian DNA topo IIalpha. Shows in vitro DNA binding activity and is likely to be part of the topo VI complex by binding to subunit A (386 aa)    
Predicted Functional Partners:
RHL2
Spo11/DNA topoisomerase VI, subunit A protein; Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Involved in cell-elongation processes; Belongs to the TOP6A family (427 aa)
       
 
  0.941
BIN4
Double-stranded DNA binding; This gene is predicted to encode a protein that forms part of the topoisomerase VI complex. BIN4 is a nuclear-localized protein that can bind DNA. bin4 mutants are brassinolide-insensitive dwarves with severely reduced cell size in leaves, roots, and hypocotyls. Proper development of root hairs and trichomes is also disrupted in bin4 mutants and they have elevated levels of double strand breaks in their cotyledon cells (454 aa)
       
 
  0.865
ELO4
Calmodulin binding;purine nucleotide binding; Elongator-associated factor that is not a structural subunit but rather transiently contacts Elongator, presumably to promote its interaction with elongation competent pol II. Regulates both meristem activity and organ growth; acts as a positive regulator of adaxial leaf patterning by modulating both cell division and differentiation. Required for an early step in synthesis of 5-carbamoylmethyl (ncm5) groups present on uridines (ncm5U) at the wobble position in tRNA; Belongs to the KTI12 family (302 aa)
           
  0.811
RGD3
DNA binding;ATP binding;nucleic acid binding;binding;helicases;ATP binding;DNA binding;helicases; Involved in meristem development. Acts as positive regulator of the CUC-STM pathway in shoot apical meristem (SAM) neo-formation; Belongs to the helicase family (2129 aa)
           
  0.795
LRL1
Transcription factor bHLH66; Encodes a basic helix-loop-helix (bHLH) protein that regulates root hair development. One of the three Arabidopsis homologs of the Lotus japonicus ROOTHAIRLESS1 (LjRHL1) gene- At2g24260 (AtLRL1), At4g30980 (AtLRL2), and At5g58010 (AtLRL3) (350 aa)
           
  0.763
MOT1
Encodes a high-affinity molybdate transporter. Mutant has reduced concentrations of molybdate in roots and shoots, and reduced shoot and root length when growing on Mo-limited medium; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family (456 aa)
           
  0.749
PARC6
Plastid division protein CDP1, chloroplastic; Component of the plastid division machinery required for PDV1 localization to constriction sites. Involved in chloroplast division site placement. Seems to inhibit FtsZ assembly, functioning as an antagonistic regulator of FtsZ dynamics against ARC6 (819 aa)
           
  0.729
AT3G42860
Zinc knuckle (CCHC-type) family protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (372 aa)
           
  0.699
TOP6B
DNA topoisomerase 6 subunit B; Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. Involved in cell-elongation processes (670 aa)
           
  0.694
AT3G14430
Uncharacterized protein At3g14430; Unknown protein; Its function is described as molecular_function unknown; Involved in response to oxidative stress; Located in mitochondrion; Expressed in 23 plant structures; Expressed during 13 growth stages; Has 16 Blast hits to 16 proteins in 7 species- Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 16; Viruses - 0; Other Eukaryotes - 0 (source- NCBI BLink) (76 aa)
           
  0.693
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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