STRINGSTRING
ACT8 protein (Arabidopsis thaliana) - STRING interaction network
"ACT8" - Actin 8 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACT8Actin 8; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins (377 aa)    
Predicted Functional Partners:
CPB
Capping protein B; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity) (256 aa)
     
 
  0.937
CPA
Capping protein A; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity) (382 aa)
     
 
  0.915
ARPC3
Actin-related protein C3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development (174 aa)
     
  0.905
CAP1
CYCLASE ASSOCIATED PROTEIN; Actin monomer binding protein that accelerates the exchange of ADP for ATP. Regulates the pool of unpolymerized ATP- actin. Key intermediate between actin-depolymerizing factor (ADF)- mediated disassembly and the profilin-based nucleation and elongation machinery (476 aa)
     
 
  0.878
ADF7
Actin depolymerizing factor 7; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers. Binds monomeric actin (G- actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin. Required for pollen tube growth. Promotes turnover of longitudinal actin cables by severing actin filaments in pollen tubes (137 aa)
     
  0.868
ADF8
Actin depolymerizing factor 8; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (140 aa)
     
  0.860
ADF10
Actin depolymerizing factor 10; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (137 aa)
     
  0.858
AT3G13350
HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain; Binds preferentially DNA with A/T-rich content (319 aa)
       
  0.856
AT1G76110
HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain; Binds preferentially DNA with A/T-rich content (PubMed-19053246). Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus (PubMed-16698901) (338 aa)
       
  0.856
AT1G04880
HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain; Binds preferentially DNA with A/T-rich content (448 aa)
       
  0.856
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (8%) [HD]