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PI4KA1 protein (Arabidopsis thaliana) - STRING interaction network
"PI4KA1" - Phosphatidylinositol 4-kinase alpha in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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PI4KA1Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Can bind to phosphatidylinositol 4- monophosphate (PI-4-P or PtdIns4P), phosphatidylinositol 4,5- bisphosphate (PI-4,5-P2 or PtdIns4,5P2), and phosphatidic acid (PtdOH), but not to 3-phosphoinositides. May function upstream of the cold response phosphoinositide-dependent phospholipase C (PI- PLC) pathway (2028 aa)    
Predicted Functional Partners:
PIP5K1
Phosphatidylinositol-4-phosphate 5-kinase 1; Catalyzes the synthesis of phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4-bisphosphate (752 aa)
     
  0.964
FAB1C
FORMS APLOID AND BINUCLEATE CELLS 1C; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity) (1648 aa)
     
  0.961
PTEN3
PTEN 3; Protein tyrosine phosphatase that exhibits also a weak lipid phosphatase activity towards PtdIns(3)P (632 aa)
     
  0.959
PTEN1
Calcium/lipid-binding (CaLB) phosphatase; Protein tyrosine phosphatase that exhibits also lipid phosphatase activity. Can use phosphatidylinositol substrates such as PtdIns(3,4,5)P(3) as substrate. Pollen-specific phosphatase required for pollen development (412 aa)
     
  0.953
PTEN2
PTEN 2; Binds phosphatidic acid. Protein tyrosine phosphatase that exhibits also lipid phosphatase activity. Hydrolyzed poorly p-nitrophenyl phosphate (p-NPP). Can use PtdIns isomers as substrates. Removes efficiently phosphate from the D3 position of the inositol ring, less from the D4 position and not at all from the D5 position on monophosphorylated PtdIns isomers (PIPs). The presence of a phosphate group in the D5 position on PIP(2) isomers reduces lipid phosphatase activity. Mostly active on PtdIns(3)P and PtdIns(3,4)P(2), to a lower extend, on PtdIns(4)P and PtdIns(3,5)P(2), but [...] (611 aa)
     
  0.953
PI-4KBETA2
Phosphatidylinositol 4-kinase 2; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5-trisphosphate (By similarity). Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB1, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB1 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway (1116 aa)
     
0.953
AT1G60890
Phosphatidylinositol-4-phosphate 5-kinase 8 (781 aa)
     
  0.952
FAB1A
FORMS APLOID AND BINUCLEATE CELLS 1A; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters (1757 aa)
     
  0.950
FAB1B
FORMS APLOID AND BINUCLEATE CELLS 1B; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters (1791 aa)
     
  0.950
PIPK10
Phosphatidylinositol phosphate kinase 10 (401 aa)
     
  0.950
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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