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LACS2 protein (Arabidopsis thaliana) - STRING interaction network
"LACS2" - Long chain acyl-CoA synthetase 2 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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LACS2Long chain acyl-CoA synthetase 2; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in the cutin pathway. Preferentially uses palmitate, palmitoleate, oleate and linoleate. Required for repression of lateral root formation through its role in cutin biosynthesis and subsequent aerial tissues permeability; Belongs to the ATP-dependent AMP-binding enzyme family (665 aa)    
Predicted Functional Partners:
CYP86A8
Cytochrome P450, family 86, subfamily A, polypeptide 8; Catalyzes the omega-hydroxylation of various fatty acids (FA). Acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18. May be involved in the biosynthesis of cutin in the epidermis which prevents post-genital organ fusions. Hydroxylated FAs may be important for trichome differentiation, establishment of apical dominance and senescence (537 aa)
     
 
  0.918
AT5G60335
Hydroxyacyl-thioester dehydratase type-like protein; Thioesterase superfamily protein; Its function is described as oxidoreductase activity; Involved in metabolic process; Contains the following InterPro domains- MaoC-like dehydratase (InterPro-IPR002539) (166 aa)
     
   
  0.890
ECH2
Encodes a monofunctional enoyl-CoA hydratase 2, involved in the degradation of even cis-unsaturated fatty acids, gene expression is enhanced during the first 2 days of germination, as well as in senescent leaves (309 aa)
     
   
  0.890
BDG1
alpha/beta-Hydrolases superfamily protein; Controls cuticle development and morphogenesis, by promoting cutin and suberin monomers loading. Involved in the regulation of abscissic acid (ABA) biosynthesis in response to osmotic stress. Plays an important role in osmotic stress and drought resistance. Required to ensure a reduced permeability of aerial tissue, thus preventing transpiration. Regulates lateral root hair development (469 aa)
     
 
  0.887
GPAT8
Probable glycerol-3-phosphate acyltransferase 8; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis (500 aa)
     
   
  0.860
GPAT4
Glycerol-3-phosphate 2-O-acyltransferase 4; Encodes a protein with glycerol-3-phosphate acyltransferase activity. Involved in cutin assembly. Is functional redundant of GPAT8; Belongs to the GPAT/DAPAT family (503 aa)
     
   
  0.848
CYP86A2
Cytochrome P450, family 86, subfamily A, polypeptide 2; Catalyzes the omega-hydroxylation of various fatty acids (FA). Acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18. Plays a major role in the biosynthesis of extracellular lipids. Involved in the biosynthesis of hydroxylated fatty acids required for cutin biosynthesis, cuticle development and repression of bacterial type III gene expression; Belongs to the cytochrome P450 family (553 aa)
     
 
  0.843
PEX5
Peroxisome biogenesis protein 5; Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal "SKL" targeting signal. The mechanism of transport has been worked out in other organisms- The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX1 [...] (728 aa)
     
   
  0.786
AT2G26800
Hydroxymethylglutaryl-CoA lyase, mitochondrial; Involved in the catabolism of branched amino acids such as leucine (468 aa)
     
   
  0.785
DCI1
Encodes the peroxisomal delta 3,5-delta2,4-dienoyl-CoA isomerase, a enzyme involved in degradation of unsaturated fatty acids. Gene expression is induced upon seed germination (278 aa)
     
   
  0.781
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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