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STRINGSTRING
TOR protein (Arabidopsis thaliana) - STRING interaction network
"TOR" - Serine/threonine-protein kinase TOR in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TORSerine/threonine-protein kinase TOR; Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival. Involved in modulating the transition from heterotrophic [...] (2481 aa)    
Predicted Functional Partners:
RAPTOR1
HEAT repeat ;WD domain, G-beta repeat protein protein; Encodes one of two Arabidopsis RAPTOR/KOG1 homologs. RAPTOR proteins are binding partners of the target of rapamycin kinase that is present in all eukaryotes and play a central role in the stimulation of cell growth and metabolism in response to nutrients. Mutants show embryo lethal phenotype which occurs at pre-globular stage. May interact with TOR kinase in a rapamycin like signaling pathway. Interacts with TOR and S6K1 in vivo. Overexpression of RAPTOR1 rendered the S6K1 osmotic stress insensitive; Belongs to the WD repeat RA [...] (1344 aa)
     
  0.999
RAPTOR2
HEAT repeat ;WD domain, G-beta repeat protein protein; Encodes one of two Arabidopsis RAPTOR/KOG1 homologs. RAPTOR proteins are binding partners of the target of rapamycin kinase that is present in all eukaryotes and play a central role in the stimulation of cell growth and metabolism in response to nutrients. Mutations in this gene have no visible effects on embryo or plant development (1336 aa)
     
  0.999
LST8-2
Transducin/WD40 repeat-like superfamily protein; Contains the following InterPro domains- WD40 repeat 2 (InterPro-IPR019782), WD40 repeat, conserved site (InterPro-IPR019775), WD40 repeat (InterPro-IPR001680), G-protein beta WD-40 repeat, region (InterPro-IPR020472), WD40 repeat-like-containing domain (InterPro-IPR011046), WD40-repeat-containing domain (InterPro-IPR017986), WD40/YVTN repeat-like-containing domain (InterPro-IPR015943), WD40 repeat, subgroup (InterPro-IPR019781); BEST Arabidopsis thaliana protein match is- Transducin/WD40 repeat-like superfamily protein (TAIR-AT3G18140.1 [...] (313 aa)
     
  0.996
LST8-1
Transducin/WD40 repeat-like superfamily protein; Contains the following InterPro domains- WD40 repeat 2 (InterPro-IPR019782), WD40 repeat, conserved site (InterPro-IPR019775), WD40 repeat (InterPro-IPR001680), G-protein beta WD-40 repeat, region (InterPro-IPR020472), WD40 repeat-like-containing domain (InterPro-IPR011046), WD40-repeat-containing domain (InterPro-IPR017986), WD40/YVTN repeat-like-containing domain (InterPro-IPR015943), WD40 repeat, subgroup (InterPro-IPR019781); BEST Arabidopsis thaliana protein match is- Transducin/WD40 repeat-like superfamily protein (TAIR-AT2G22040.1 [...] (305 aa)
     
  0.996
FKBP12
Peptidyl-prolyl cis-trans isomerase FKBP12; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Mediates rapamycin inactivation of TOR protein kinase activity (112 aa)
       
 
  0.994
LBA1
Regulator of nonsense transcripts 1 homolog; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the production of nonsense-containing RNAs (ncRNAs). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding; Belongs to the DNA2/NAM7 helicase family (1254 aa)
     
 
  0.991
PK1
Serine/threonine-protein kinase AtPK1/AtPK6; Encodes a protein-serine kinase that phosphorylates ribosomal protein in vitro. Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Involved in translational up-regulation of ribosomal proteins. Phosphorylated by PDK1. Interacts with RAPTOR1, which in turn interacts with TOR. SPK6 activity is affected by osmotic stress, and plants overexpressing S6k1 are hypersensitive to osmotic stress. The gene is expressed in all tissues examined, with highest expression level det [...] (465 aa)
       
 
  0.979
AT2G39260
Regulator of nonsense transcripts UPF2; Recruited by UPF3 associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Required for plant develo [...] (1181 aa)
     
 
  0.973
AT2G20050
Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein; Protein serine/threonine phosphatases;protein kinases;catalytics;cAMP-dependent protein kinase regulators;ATP binding;protein serine/threonine phosphatases; Its function is described as cAMP-dependent protein kinase regulator activity, protein kinase activity, protein serine/threonine phosphatase activity, catalytic activity, ATP binding; Involved in protein amino acid phosphorylation, protein amino acid dephosphorylation, N-terminal protein myristoylation, regulation of protein amino acid phosphoryl [...] (1094 aa)
     
 
  0.972
AT1G79190
ARM repeat superfamily protein; Its function is described as binding; Involved in biological_process unknown; Located in cellular_component unknown; Expressed in 20 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Armadillo-type fold (InterPro-IPR016024); Has 200 Blast hits to 184 proteins in 98 species- Archae - 0; Bacteria - 0; Metazoa - 76; Fungi - 76; Plants - 39; Viruses - 0; Other Eukaryotes - 9 (source- NCBI BLink) (1335 aa)
     
 
  0.966
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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