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SIRB protein (Arabidopsis thaliana) - STRING interaction network
"SIRB" - Sirohydrochlorin ferrochelatase B in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SIRBSirohydrochlorin ferrochelatase B; Chelates iron to the siroheme precursor. Catalyzes the last step of the siroheme biosynthesis. Unlike its counterparts in bacteria, contains an [Fe-S] cluster which is not involved directly in the enzymatic reaction, but may play regulatory role in iron, sulfur and tetrapyrrole metabolism (PubMed-15545265, PubMed-22414210). The [Fe-S] cluster is required for normal plant growth (PubMed-22414210) (225 aa)    
Predicted Functional Partners:
UPM1
Urophorphyrin methylase 1 (369 aa)
 
 
  0.977
NIR1
Nitrite reductase 1; Catalyzes the six-electron reduction of nitrite to ammonium (586 aa)
   
   
  0.745
SIR
Sulfite reductase; Essential protein with sulfite reductase activity required in assimilatory sulfate reduction pathway during both primary and secondary metabolism and thus involved in development and growth (642 aa)
   
   
  0.732
CHLI2
Magnesium chelatase i2; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step. Possesses low affinity for ATP and may play a limited role in chlorophyll biosynthesis, and contributes to the assembly of the Mg-chelatase complex (418 aa)
         
  0.725
URO
UPRIGHT ROSETTE (172 aa)
           
  0.708
HEMA1
glutamyl-tRNA reductase 1; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA). Probably involved in the tetrapyrrole synthesis required for the chlorophyll biosynthesis (543 aa)
         
  0.613
CHLI1
Magnesium-chelatase subunit chlI; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX. The magnesium-chelatase is a complex of three subunits, CHLI, CHLD and CHLH. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP- dependent chelation step. Possesses high affinity for ATP and may play a major role in chlorophyll biosynthesis. Does not bind abscisic acid (ABA), but is a positive regulator of ABA signaling (424 aa)
   
   
  0.607
AT1G71500
Rieske (2Fe-2S) domain-containing protein (287 aa)
   
        0.581
NRT2.3
Nitrate transporter 2.3; Involved in high-affinity nitrate transport. Acts as a dual component transporter with NTR3.1 (By similarity) (539 aa)
   
        0.567
NRT2.4
Nitrate transporter 2.4; Involved in high-affinity nitrate transport. Might be involved in the transfer of nitrate from stored pools to cytoplasm (527 aa)
   
        0.567
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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