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HIT1 protein (Arabidopsis thaliana) - STRING interaction network
"HIT1" - Vacuolar protein sorting-associated protein 53 A in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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HIT1Vacuolar protein sorting-associated protein 53 A; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Required for vesicle trafficking involved in plasma membrane protein composition. Probably involved in pollen tube elongation and other polar growth. Confers basal tolerance to long-term heat stress and osmotic stress, by acclimation of the plasma membrane; Belongs to the VPS53 family (847 aa)    
Predicted Functional Partners:
VPS54
Vacuolar protein sorting-associated protein 54, chloroplastic; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Probably involved in pollen tube elongation and other polar growth; Belongs to the VPS54 family (1034 aa)
     
  0.999
POK
Vacuolar protein sorting-associated protein 52 A; Encodes a homolog of the yeast Vps52p/SAC2. Involved in pollen tube germination and growth. Located in multiple endomembrane organelles including the golgi. The yeast protein has been shown to be located at the late Golgi and to function in a complex involved in retrograde trafficking of vesicles between the early endosomal compartment and the trans-Golgi network (707 aa)
     
  0.999
AT4G02030
Vps51/Vps67 family (components of vesicular transport) protein; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP [...] (805 aa)
     
  0.999
AT2G27900
Uncharacterized protein At2g27890-At2g27900-At2g27910; Contains the following InterPro domains- Protein of unknown function DUF2451, C-terminal (InterPro-IPR019514), Vacuolar protein sorting-associated protein 54 (InterPro-IPR019515); Has 35333 Blast hits to 34131 proteins in 2444 species- Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source- NCBI BLink) (1124 aa)
     
 
  0.984
AT1G71300
Vacuolar protein sorting-associated protein 52 B; May be involved in retrograde transport of early and late endosomes to the late Golgi; Belongs to the VPS52 family (721 aa)
     
  0.967
AT4G01400
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function (1110 aa)
     
 
  0.957
ATZW10
Centromere/kinetochore protein, putative (ZW10); May be required for accurate chromosome segregation. Required for proper maturation of seed storage proteins. Forms a complex with MAG2, MIP2 and MIP3 on the endoplasmic reticulum that may be responsible for efficient transport of seed storage proteins; Belongs to the ZW10 family (742 aa)
     
   
  0.902
SEC10
Exocyst complex component SEC10a; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall; Belongs to the SEC10 family (825 aa)
     
   
  0.885
SEC6
Exocyst complex component SEC6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall; Belongs to the SEC6 family (774 aa)
     
   
  0.874
VPS45
Vacuolar protein sorting-associated protein 45 homolog; A peripheral membrane protein that associates with microsomal membranes, likely to function in the transport of proteins to the vacuole. It is a member of Sec1p protein family. It may be involved in the regulation of vesicle fusion reactions through interaction with t-SNAREs at the Golgi trans face (569 aa)
     
 
  0.856
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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