STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hrd1BERAD-associated E3 ubiquitin-protein ligase HRD1B; Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3A (460 aa)    
Predicted Functional Partners:
OS9
Protein OS-9 homolog; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Targets the misfolded LRR receptor kinase BRI1 and the misfolded receptor-like kinase EFR; Belongs to the OS-9 family
   
 0.998
EBS5
ERAD-associated E3 ubiquitin-protein ligase component HRD3A; Component of the endoplasmic reticulum (ER) quality control system called ER-associated degradation (ERAD) and involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Functions as an ERAD substrate- recruiting factor that recognizes misfolded proteins for the HRD1 E3 ubiquitin ligase complex. Targets the misfolded LRR receptor kinase BRI1
   
 0.989
CDC48
Encodes a cell division cycle protein, a member of AAA-type ATPases gene family. Expressed throughout the plant in regions of cell division. Within the cell, sub-cellular localization varies depending on the stage of the cell cycle.Mutants in which the expression of CDC48A is altered show defects in cytokinesis, cell expansion and cell differentiation
    
 0.986
DER2.2
DERLIN-2.2; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins
   
 0.981
DER2.1
DERLIN-2.1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins
   
 0.981
AT1G73570
ERAD-associated E3 ubiquitin-protein ligase component HRD3B; May be involved in the endoplasmic reticulum (ER) quality control system called ER-associated degradation (ERAD)
   
 0.977
AtCDC48B
Cell division control protein 48 homolog D; Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity)
   
 0.975
AtCDC48C
Cell division control protein 48 homolog E; Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity)
    
 0.973
AT1G53930
Ubiquitin-like superfamily protein; Contains the following InterPro domains: Ubiquitin subgroup (InterPro:IPR019956), Ubiquitin conserved site (InterPro:IPR019954), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: polyubiquitin 10 (TAIR:AT4G05320.6); Has 11184 Blast hits to 6096 proteins in 709 species: Archae - 0; Bacteria - 19; Metazoa - 4709; Fungi - 1331; Plants - 2917; Viruses - 171; Other Eukaryotes - 2037 (source: NCBI BLink)
    
 0.928
AT1G53950
Ubiquitin-like superfamily protein; Contains the following InterPro domains: Ubiquitin subgroup (InterPro:IPR019956), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: Ubiquitin family protein (TAIR:AT4G02890.4); Has 10458 Blast hits to 4586 proteins in 685 species: Archae - 0; Bacteria - 26; Metazoa - 4341; Fungi - 1141; Plants - 2617; Viruses - 325; Other Eukaryotes - 2008 (source: NCBI BLink)
    
 0.928
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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