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EMB2813 protein (Arabidopsis thaliana) - STRING interaction network
"EMB2813" - Probable DNA primase large subunit in Arabidopsis thaliana
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Predicted Interactions
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textmining
co-expression
protein homology
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EMB2813Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family (490 aa)    
Predicted Functional Partners:
POLA2
DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (620 aa)
     
  0.999
POLA3
DNA primases;DNA primases; POLA3; Its function is described as DNA primase activity; Involved in DNA replication, synthesis of RNA primer, DNA replication; Expressed in 20 plant structures; Expressed during 14 growth stages; Contains the following InterPro domains- DNA primase, small subunit (InterPro-IPR002755), DNA primase, small subunit, eukaryotic/archaeal (InterPro-IPR014052); Has 510 Blast hits to 504 proteins in 249 species- Archae - 95; Bacteria - 0; Metazoa - 124; Fungi - 138; Plants - 44; Viruses - 0; Other Eukaryotes - 109 (source- NCBI BLink) (451 aa)
   
  0.999
ICU2
Encodes the putative catalytic subunit of the DNA polymerase alpha. Interacts with genes involved in chromatin-mediated cellular memory. ICU2 genetically interacts with TERMINAL FLOWER2, the ortholog of HETEROCHROMATIN PROTEIN1 of animals and yeasts, and with the Polycomb group (PcG) gene CURLY LEAF. A number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. Mutant has curled, involute leaves and causes early flowering (1524 aa)
     
  0.999
TIL2
Encodes a protein with similarity to DNA polymerase epsilon catalytic subunit. Based on yeast two hybrid analysis, not predicted to be a subunit of the DNA polymerase epsilon complex. No phenotype observed in homozygous mutant embryos or plants but in combination with TIL1-1/til1-1 heterozygotes arrest earlier than til1 homozygotes suggesting TIL2 functions redundantly with TIL1 (2138 aa)
     
  0.999
TIL1
DNA polymerase epsilon catalytic subunit A; DNA polymerase II, which participates in chromosomal DNA replication. Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning. Necessary for proper shoot (SAM) and root apical meristem (RAM) functions. Involved in maintaining epigenetic states, controlling hypersensitive response (HR), and mediating abscisic acid (ABA) signaling. Required for flowering repression through a mechanism involving epigenetic gene silencing. May participate in proc [...] (2161 aa)
     
  0.999
EMB2780
DNA polymerase delta catalytic subunit; This polymerase possesses two enzymatic activities- DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’- to 5’-direction (1112 aa)
     
  0.999
POLD2
DNA polymerase delta small subunit; The function of the small subunit is not yet clear (441 aa)
   
  0.999
EMB2775
ATPase family associated with various cellular activities (AAA); A locus involved in embryogenesis. Mutations in this locus result in embryo lethality (354 aa)
     
  0.998
PCNA1
Proliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand; Belongs to the PCNA family (263 aa)
   
 
  0.998
MCM2
Minichromosome maintenance (MCM2/3/5) family protein; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. May play a crucial role in the control of de-differentiation and cell proliferation processes required for lateral root formation. Is essential for embryo development. Is involved in the geminivirus mungbean yellow mosaic virus (MYMV) DNA replication, presumably in conjunction with other host factors (936 aa)
     
  0.998
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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